From: Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer
miR-BART | Target | Function | Disease | Reference |
---|---|---|---|---|
miR-BART13-3p | Tumor suppressor AB12 | EMT | HL, NPC | [32] |
mR-BART19-3p | Unknown | – | HL, NPC, ENKL | [23] |
miR-BART2-5P | MICB BALF5 | Ligand for activator NKG2D NK receptor RNA polymerase II and B-cell receptor NFKB activation | GC, NPC HL, ENKL | |
miR-BART7-3p | phosphatase and tensin homolog (PTEN) mothers against decapentaplegic homolog 7 (SMAD7) | Tumor suppressor, pro- inflammatory, stem-like | GC | |
miR-BART4-5p | BH3 interacting-domain death agonist (Bid) | Pro-apoptotic protein | GC | [56] |
miR-BART17-5p | DNA transcription factor Kruppel-like factor 2 (KLF2) | Energy metabolism inflammation | GC | |
miR-BART I,II cluster | bcl2-interacting mediators of cell death (Bim) | Pro-apoptotic protein Autophagy | GC | [61] |
miR-BART3-3p | TP53 | tumor suppressor | GC | [62] |
miR-BART5-Â 3p | TP53 PIAS3 | tumor suppressor inhibitor of pSTAT and pDL-1 | GC | |
miR-BART15-5p | NLRP3 inflammasome BRUCE and TAX1BP1 | pro-inflammatory cytokines such as IL-1β and IL-18, gasdermin D- mediated pyroptotic cell death apoptosis | GC |