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Table 2 miR-BART targets and their functions in different cancers

From: Epstein-Barr virus BART microRNAs in EBV- associated Hodgkin lymphoma and gastric cancer

miR-BART

Target

Function

Disease

Reference

miR-BART13-3p

Tumor suppressor AB12

EMT

HL, NPC

[32]

mR-BART19-3p

Unknown

–

HL, NPC, ENKL

[23]

miR-BART2-5P

MICB BALF5

Ligand for activator NKG2D NK receptor

RNA polymerase II and B-cell receptor NFKB activation

GC, NPC HL, ENKL

[34,35,36,37,38]

miR-BART7-3p

phosphatase and tensin homolog (PTEN) mothers against decapentaplegic homolog 7 (SMAD7)

Tumor suppressor, pro- inflammatory, stem-like

GC

[56,57,58]

miR-BART4-5p

BH3 interacting-domain death agonist (Bid)

Pro-apoptotic protein

GC

[56]

miR-BART17-5p

DNA transcription factor Kruppel-like factor 2 (KLF2)

Energy metabolism inflammation

GC

[59, 60]

miR-BART I,II

cluster

bcl2-interacting mediators of cell death (Bim)

Pro-apoptotic protein Autophagy

GC

[61]

miR-BART3-3p

TP53

tumor suppressor

GC

[62]

miR-BART5- 3p

TP53 PIAS3

tumor suppressor inhibitor of pSTAT and pDL-1

GC

[44, 63]

miR-BART15-5p

NLRP3 inflammasome BRUCE and TAX1BP1

pro-inflammatory cytokines such as IL-1β and IL-18, gasdermin D- mediated pyroptotic cell death apoptosis

GC

[64,65,66]

  1. EMT Epithelial-mesenchymal transition; ENKL Nasal NK7T-cell lymphoma; GC Gastric cancer; HL Hodgkin lymphoma; NPC Nasopharyngeal carcinoma