Risk of cervical lesions in high-risk HPV positive women with normal cytology: a retrospective single-center study in China

Table 3 Distribution of hr-HPV genotypes and histological results among hr-HPV-positive/cytology-negative women

HPV Type(s)	Histological Results
HPV Type(s)	TOTAL	NORMAL(n,%)	LSIL(n,%)	HSIL(n,%)	CA(n,%)	HSIL+(n,%)	HSIL+ OR(95% CI)
HPV infection(s) with 16 and/or 18
HPV16	1047	522 (49.86)	169 (16.14)	325 (31.04)	31 (2.96)	356 (34.00)
HPV18	270	175 (64.81)	61 (22.59)	30 (11.11)	4 (1.48)	34 (12.59)
16 + other(s)^a	492	213 (43.29)	105 (21.34)	166 (33.74)	8 (1.63)	174 (35.37)
18 + other(s)^a	120	56 (46.67)	38 (31.67)	26 (21.67)	0 (0.00)	26 (21.67)
16 + 18 + other(s) ^a	79	30 (37.97)	17 (21.52)	31 (39.24)	1 (1.27)	32 (40.51)
No. of hr HPV type(s) without HPV16 or 18
1 type^b	839	558 (66.51)	178 (21.22)	101 (12.04)	2 (0.24)	103 (12.28)	1
2 types^c	192	118 (61.46)	35 (18.23)	39 (20.31)	0 (0.00)	39 (20.31)	1.821 (1.212–2.738)
≥ 3 types^d	40	19 (47.50)	6 (15.00)	15 (37.50)	0 (0.00)	15 (37.50)	4.287 (2.188–8.400)
Unknown type(s)
HC2^e	1548	984 (63.57)	300 (19.38)	247 (15.96)	17 (1.10)	264 (17.05)
12 hr-HPV^f	1253	851 (67.92)	246 (19.63)	156 (12.45)	0 (0.00)	156 (12.45)
Total
N^g	5880	3526 (59.97)	1155 (19.64)	1136 (19.32)	63 (1.07)	1199 (20.39)

HPV human papillomavirus
hr-HPV high-risk human papillomavirus
LSIL low-grade squamous intraepithelial lesion
HSIL high-grade squamous intraepithelial lesion
CA cervical cancer
HSIL+ high-grade squamous intraepithelial lesion or worse
OR odds ratio
CI confidence interval
^a=hr-HPV genotypes except HPV16 or 18
^b= single hr-HPV infection without HPV16 or 18
^c= double hr-HPV infections HPV16 or 18
^d= triple or more hr-HPV infections HPV16 or 18
^e= infection(s) with a pool of 12 other hr-HPV types (including HPV 31,33,35,39,45,51,52,56,58,59,66 and 68) that did not know the specific type of HPV (from Cobas 4800 HPV test)
^f=13 hr-HPV types (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59 and 68) tested by Hybrid Capture 2(HC2)High-Risk HPV DNA Test
^g=The total number of people with hr-HPV positive in the corresponding histological results groups

ISSN: 1750-9378