Fig. 5

Role of IL-12 in LDV-mediated protection against AB1 growth. a Survival of groups of 8 LDV-infected BALB/c mice either without (open circles) or with anti-IL-12 mAb treatment (closed circles) was monitored daily after i.p. administration of AB1 cells. b IFN-γ was measured by ELISA in groups of 5 BALB/C mice 18 h after LDV infection with and without anti-IL-12 mAb treatment (500 μg 24 h before infection). c Flow cytometry analysis of IFN-γ–producing spleen NK cells 18 h after LDV infection with and without anti-IL-12 mAb treatment (same animals as in B). Results are shown as means ± SEM