Role of human papillomavirus infection in the etiology of vulvar cancer in Italian women

Table 1 HPV DNA, RNA, and p16 positivity in 102 VSCC and 7 MTS cases

		VSCC (N = 102)	MTS (N = 7)
HPV type	Marker positivity	Positive n (%)	Positive n (%)
Any HPV	DNA	17 (16.7)	7 (100.0)
	DNA and RNA^a	8 (7.8)	1 (14.3)
	DNA, RNA, and p16^a	5 (4.9)	1 (14.3)
HPV16 single infection	DNA	9 (8.8)	1 (14.3)
	DNA and RNA	5 (4.9)	0 (0.0)
	DNA, RNA, and p16	4 (3.9)	0 (0.0)
Mucosal HPV other than HPV16 single infections	DNA	7 (6.9)^b	4 (57.1)^d
	DNA and RNA	2 (2.0)^c	0 (0.0)
	DNA, RNA, and p16	0 (0.0)	0 (0.0)
Multiple infections	DNA	1 (1.0)^e	2 (28.6)^g
	DNA and RNA	1 (1.0)^f	1 (14.3)^h
	DNA, RNA, and p16	1 (1.0)	1 (14.3)

HPV Human papillomavirus, MTS Metastatic lymph node samples, VSCC Vulvar squamous cell carcinoma
^aHPV RNA was examined in 17 VSCC and 7 MTS HPV DNA-positive cases and a randomly selected subset of HPV DNA-negative cases (n = 10). p16 expression was examined in all VSCC (n = 102) and MTS (n = 7) cases
^bSingle infections: HPV6 (n = 2), HPV18 (n = 1), HPV53 (n = 1), HPV56 (n = 1), HPV58 (n = 1), HPV82 (n = 1)
^cSingle infections: HPV53 (n = 1), HPV58 (n = 1)
^dSingle infections: HPV6 (n = 3), HPV56 (n = 1)
^eCoinfection: HPV16, HPV18, and HPV56 (n = 1)
^fCoinfection: HPV16 and HPV56 (n = 1)
^gCoinfection: HPV6 and HPV16 (n = 2)
^hSingle infection: HPV16 (n = 1)

ISSN: 1750-9378