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Table 1 HPV DNA, RNA, and p16 positivity in 102 VSCC and 7 MTS cases

From: Role of human papillomavirus infection in the etiology of vulvar cancer in Italian women

  VSCC (N = 102)MTS (N = 7)
HPV typeMarker positivityPositive
n (%)
Positive
n (%)
Any HPVDNA17 (16.7)7 (100.0)
DNA and RNAa8 (7.8)1 (14.3)
DNA, RNA, and p16a5 (4.9)1 (14.3)
HPV16 single infectionDNA9 (8.8)1 (14.3)
DNA and RNA5 (4.9)0 (0.0)
DNA, RNA, and p164 (3.9)0 (0.0)
Mucosal HPV other than HPV16 single infectionsDNA7 (6.9)b4 (57.1)d
DNA and RNA2 (2.0)c0 (0.0)
DNA, RNA, and p160 (0.0)0 (0.0)
Multiple infectionsDNA1 (1.0)e2 (28.6)g
DNA and RNA1 (1.0)f1 (14.3)h
DNA, RNA, and p161 (1.0)1 (14.3)
  1. HPV Human papillomavirus, MTS Metastatic lymph node samples, VSCC Vulvar squamous cell carcinoma
  2. aHPV RNA was examined in 17 VSCC and 7 MTS HPV DNA-positive cases and a randomly selected subset of HPV DNA-negative cases (n = 10). p16 expression was examined in all VSCC (n = 102) and MTS (n = 7) cases
  3. bSingle infections: HPV6 (n = 2), HPV18 (n = 1), HPV53 (n = 1), HPV56 (n = 1), HPV58 (n = 1), HPV82 (n = 1)
  4. cSingle infections: HPV53 (n = 1), HPV58 (n = 1)
  5. dSingle infections: HPV6 (n = 3), HPV56 (n = 1)
  6. eCoinfection: HPV16, HPV18, and HPV56 (n = 1)
  7. fCoinfection: HPV16 and HPV56 (n = 1)
  8. gCoinfection: HPV6 and HPV16 (n = 2)
  9. hSingle infection: HPV16 (n = 1)