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Table 2 Comparison of serological indices, inflammation grade and fibrosis grade in HBV DNA negative and positive hepatitis B patients after 12-month follow up

From: Pathological changes of liver one year later in CHB patients with negative HBV DNA

Test Index

Group A

Group B

Baseline level

12 months later

Baseline level

12 months later

ALT(U/L)

37.77 ± 41.74

30.21 ± 32.37

40.77 ± 34.72

51.08 ± 47.36@

AST(U/L)

30.41 ± 20.97

31.74 ± 35.14

33.92 ± 17.17

43.92 ± 35.53

TBIL (μmol/L)

14.73 ± 6.09

14.78 ± 5.98

10.92 ± 2.76#

11.55 ± 3.65

DBIL (μmol/L)

4.70 ± 4.69

4.53 ± 1.98

2.90 ± 1.11#

3.25 ± 1.30@

ALB(g/L)

47.71 ± 3.66

46.22 ± 3.12*

46.37 ± 5.10

44.58 ± 6.14

GLB(g/L)

27.49 ± 4.51

28.17 ± 4.17

27.07 ± 4.86

28.79 ± 4.98

ALP(U/L)

71.09 ± 23.62

67.75 ± 18.85

67.54 ± 23.49

69.31 ± 23.36

γ-GT (U/L)

30.68 ± 29.56

29.34 ± 23.59

24.08 ± 20.56

26.92 ± 21.25

PT(s)

11.83 ± 0.92

11.23 ± 0.89*

11.29 ± 0.82

10.95 ± 0.92

PTA(%)

94.34 ± 10.15

107.89 ± 9.58*

98.90 ± 8.64

113.06 ± 16.98&

WBC(10E9/L)

5.36 ± 1.36

5.87 ± 1.78

6.18 ± 1.82

6.60 ± 2.43

PLT(10E9/L)

158.68 ± 55.02

159.78 ± 45.61

170.33 ± 48.66

168.62 ± 36.71

AFP (ng/mL)

4.05 ± 2.94

2.85 ± 1.63*

3.60 ± 1.79

3.86 ± 3.85

Inflammation Grade

1.42 ± 0.63

1.37 ± 0.59

1.00 ± 0.41#

1.38 ± 0.51&

Fibrosis Stage

1.38 ± 1.14

1.60 ± 1.05

0.85 ± 0.69

1.31 ± 0.85

HBeAg (Positive)!

33 (41.77%)

25 (31.65%)

7 (53.85%)

3 (23.08%)

  1. *P < 0.05 versus the value of the baseline level of group A
  2. &P < 0.05 versus the value of the baseline level of group B
  3. #P < 0.05 versus the value of the baseline level of group A
  4. @P < 0.05 versus the value of 12 months later of group A
  5. ! no. (%)