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Table 4 Additional human orthologs of fish TTRgrEEN genes, according to OMA ortholog search algorithm, with functions that do not exist in fish

From: Evolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans

Name of gene (Fish gene/Human gene)GO domainSelected GO progressive functions not encountered in fish
Molecular function (Fish gene/Human gene)Cellular component (Fish gene/Human gene)Biological process (Fish gene/Human gene)([Fish gene]/[Human gene])
Fish atxn1l/Human ATXN1L1 / 31 / 50 / 10[NO] / lung alveolus development
Fish id2a/Human ID21 / 32 / 48 / 56[NO]/epithelial cell differentiation involved in mammary gland alveolus development, mammary gland epithelial cell proliferation, mammary gland alveolus development, ventricular septum development
Fish ccr11.1/Human CX3CR13 / 42 / 74 / 17[NO] / cerebral cortex cell migration
HFish cntnap2a/Human CNTNAP20 / 22 / 151 / 8[NO] / cerebral cortex development
Fish mycn/Human MYCN2 / 71 / 31 / 20[NO] / lung development
Fish neflb/Human NEFL1 / 102 / 101 / 29[NO] / cerebral cortex development
Fish notch1b/Human NOTCH13 / 151 / 2015 / 162[NO] / lung development
Fish notch1b/Human NOTCH20 / 50 / 47 / 8[NO] / embryo implantation
Fish notch1b/Human NOTCH32 / 72 / 114 / 40[NO] / cerebral cortex development
Fish notch1b/Human NOTCH42 / 33 / 94 / 42[NO]/trachea cartilage morphogenesis, lobar bronchus development, lung epithelium development, lung development, lung morphogenesis, chorio-allantoic fusion, embryonic placenta morphogenesis, mammary gland epithelium development
Fish notch1b/Human NOTCH57 / 302 / 86 / 81[NO]/placenta development