Table 4 Additional human orthologs of fish TTRgrEEN genes, according to OMA ortholog search algorithm, with functions that do not exist in fish
Name of gene (Fish gene/Human gene) | GO domain | Selected GO progressive functions not encountered in fish | ||
|---|---|---|---|---|
Molecular function (Fish gene/Human gene) | Cellular component (Fish gene/Human gene) | Biological process (Fish gene/Human gene) | ([Fish gene]/[Human gene]) | |
Fish atxn1l/Human ATXN1L | 1 / 3 | 1 / 5 | 0 / 10 | [NO] / lung alveolus development |
Fish id2a/Human ID2 | 1 / 3 | 2 / 4 | 8 / 56 | [NO]/epithelial cell differentiation involved in mammary gland alveolus development, mammary gland epithelial cell proliferation, mammary gland alveolus development, ventricular septum development |
Fish ccr11.1/Human CX3CR1 | 3 / 4 | 2 / 7 | 4 / 17 | [NO] / cerebral cortex cell migration |
HFish cntnap2a/Human CNTNAP2 | 0 / 2 | 2 / 15 | 1 / 8 | [NO] / cerebral cortex development |
Fish mycn/Human MYCN | 2 / 7 | 1 / 3 | 1 / 20 | [NO] / lung development |
Fish neflb/Human NEFL | 1 / 10 | 2 / 10 | 1 / 29 | [NO] / cerebral cortex development |
Fish notch1b/Human NOTCH1 | 3 / 15 | 1 / 20 | 15 / 162 | [NO] / lung development |
Fish notch1b/Human NOTCH2 | 0 / 5 | 0 / 4 | 7 / 8 | [NO] / embryo implantation |
Fish notch1b/Human NOTCH3 | 2 / 7 | 2 / 11 | 4 / 40 | [NO] / cerebral cortex development |
Fish notch1b/Human NOTCH4 | 2 / 3 | 3 / 9 | 4 / 42 | [NO]/trachea cartilage morphogenesis, lobar bronchus development, lung epithelium development, lung development, lung morphogenesis, chorio-allantoic fusion, embryonic placenta morphogenesis, mammary gland epithelium development |
Fish notch1b/Human NOTCH5 | 7 / 30 | 2 / 8 | 6 / 81 | [NO]/placenta development |