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Table 3 Selected human orthologs of fish TTRgrEEN genes with functions that do not exist in fish

From: Evolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans

Name of ene (Fish gene/Human gene)

GO domain

Selected GO progressive functions not encountered in fish ([Fish gene]/[Human gene])

Molecular function (Fish gene/Human gene)

Cellular component (Fish gene/Human gene)

Biological process (Fish gene/Human gene)

Fish tgfbr2b/Human TGFBR2

10/18

4/12

9/84

[NO]/[bronchus development, bronchus morphogenesis, embryo implantation, in utero embryonic development, lung development, lung lobe morphogenesis, lung morphogenesis, mammary gland morphogenesis, ventricular septum development]

Fish lepa/Human LEP

2/4

3/3

15/106

[NO]/[placenta development

Fish sema7a/Human SEMA7A

1/3

0/4

1/16

[NO]/[olfactory lobe development

Fish klf1/Human KLF1

3/7

1/2

3/6

[NO]/[maternal process involved in female pregnancy

Fish ephb3a/Human EPHB3

7/9

3/8

5/25

[NO]/corpus callosum development

Fish dazap1/Human DAZAP1

2/6

0/6

0/6

[NO]/maternal placenta development

Fish spry1/Human SPRY1

0/1

1/6

6/16

[NO]/bud elongation involved in lung branching

Fish lmx1bb/Human LMX1B

3/7

1/1

13/9

[NO]/in utero embryonic development

Fish nr2e1/Human NR2E1

5/9

1/2

2/41

[NO]/cerebral cortex development, cerebral cortex neuron differentiation, dentate gyrus development, layer formation in cerebral cortex

Fish sobpa/Human SOBP

0/2

0/1

0/5

[NO]/cochlea development

Fish ccdc40/Human CCDC40

0/0

4/5

11/14

[NO]/lung development

Fish fosl1a/Human FOSL1

0/7

0/6

0/29

[NO]/placenta blood vessel development