TY - JOUR AU - Matyunina, E. A. AU - Emelyanov, A. V. AU - Kurbatova, T. V. AU - Makashov, A. A. AU - Mizgirev, I. V. AU - Kozlov, A. P. PY - 2019 DA - 2019/12/05 TI - Evolutionarily novel genes are expressed in transgenic fish tumors and their orthologs are involved in development of progressive traits in humans JO - Infectious Agents and Cancer SP - 46 VL - 14 IS - 1 AB - Earlier we suggested a new hypothesis of the possible evolutionary role of hereditary tumors (Kozlov, Evolution by tumor Neofunctionalization, 2014), and described a new class of genes – tumor specifically expressed, evolutionarily novel (TSEEN) genes - that are predicted by this hypothesis (Kozlov, Infect Agents Cancer 11:34, 2016). In this paper we studied evolutionarily novel genes expressed in fish tumors after regression, as a model of evolving organs. As evolutionarily novel genes may not yet have organismal functions, we studied the acquisition of new gene functions by comparing fish evolutionarily novel genes with their human orthologs. We found that many genes involved in development of progressive traits in humans (lung, mammary gland, placenta, ventricular septum, etc.) originated in fish and are expressed in fish tumors and tumors after regression. These findings support a possible evolutionary role of hereditary tumors, and in particular the hypothesis of evolution by tumor neofunctionalization. SN - 1750-9378 UR - https://doi.org/10.1186/s13027-019-0262-5 DO - 10.1186/s13027-019-0262-5 ID - Matyunina2019 ER -