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Table 4 HPV E6/E7 gene variations and amino acid substitutions in the case and control groups

From: Phylogeny and polymorphism in the E6 and E7 of human papillomavirus: alpha-9 (HPV16, 31, 33, 52, 58), alpha-5 (HPV51), alpha-6 (HPV53, 66), alpha-7 (HPV18, 39, 59, 68) and alpha-10 (HPV6, 44) in women from Shanghai

HPVGenomeAminoCasebControlcP value*
positionaacidaMutationFrequency(%)MutationFrequency (%)
HPV16
E6 case (n=23)
control (n=10)
T7179GL19V14.300.01.000
T7220GD32E2087.0550.00.036
C7377TH85Y00.0110.00.303
G7384CC87S28.700.01.000
A7404TT94S313.0110.01.000
A7484CE120D14.3110.00.521
E7 case (n=21)
control (n=10)
A7688CN29H00.0110.00.323
A7689GN29S1990.5550.00.022
C7832TR77C14.8110.01.000
HPV31
E6 case (n=4)
control (n=9)
C285TH60Y00.0333.30.497
A297GT64A00.0111.11.000
A475GK123R00.0111.11.000
C520TA138V00.0444.40.228
E7 case (n=4)
control (n=9)
C626TH23K4100.0666.70.497
G695AE46K00.0444.40.228
A743GK62E4100.09100.0
HPV33
E6 case (n=9)
control (n=6)
A213CK35N333.3233.31.000
A364CN86H333.3233.31.000
A387CK93N333.3116.70.604
A446GQ113R333.3116.70.604
E7 case (n=9)
control (n=6)
A834GN88D111.100.01.000
C850AT93N111.100.01.000
A862TQ97L333.3233.31.000
HPV52
E6 case (n=13)
control (n=17)
G108CE3Q00.015.91.000
E7 case (n=27)
control (n=26)
C624GC24W00.013.80.491
C662TT37I13.700.01.000
G707AS52D13.700.01.000
T727GY59D13.700.01.000
C733TH61Y13.700.01.000
G742AD64N13.700.01.000
T848GL99R13.700.01.000
HPV58
E6 case (n=25)
control (n=18)
G203CE32Q312.015.60.628
C228TS40F14.000.01.000
C367AD86E28.0211.11.000
A388CK93N14.0633.30.015
A544TK145S00.015.60.419
E7 case (n=12)
control (n=9)
C632TT20I325.0333.31.000
G694AG41R325.0222.21.000
C755AT61N00.0111.10.429
G760AG63S433.3222.20.659
G761AG63D325.0222.21.000
A793GT74A18.300.01.000
C801AD76E18.300.01.000
T803CV77A00.0333.30.063
  1. HPV Human papillomavirus; aThe reference HPV16/31/33/52/58 E6/E7 gene sequence was NC_001526, J04353.1, M12732.1, NC_001592.1, and D90400. bHSIL group, cLSIL and IF group. * Fisher's exact test P value, and the bold numbers refer P value less than 0.05