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Fig. 1 | Infectious Agents and Cancer

Fig. 1

From: B7-H4 is highly expressed in aggressive Epstein-Barr virus positive diffuse large B-cell lymphoma and inhibits apoptosis through upregulating Erk1/2 and Akt signalling pathways

Fig. 1

Histopathological features and survival analysis of patients with DLBCL. a-b ISH-EBER shows positivity with brown staining, (a) 20 × 40 and (b) 40 × 40. c-d. ISH-EBER shows negativity, (c) 20 × 40 and (d) 40 × 40. e Different sample from EBV+DLBCL patients was subjected to IHC staining using B7-H4 antibody 3E8. Normal mouse IgG was used as the negative control (Data not shown). Representative DLBCL sample with positive B7-H4 expression was used by Semi-quantitative measurement. Total score of this sample is 5 (intensity 3 plus proportion 2). f-g Overall survival (OS) (f) and progression-free survival (PFS) (g) EBV+DLBCL (n = 16) and EBVDLBCL (n = 244). EBV+DLBCL patients had poorer prognoses than EBVDLBCL patients (2 year OS rate: 51.9% vs 84.9%, P = 0.0001; 2 year PFS rate: 51.9% vs 80.3%, P = 0.0015)

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