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Table 4 Positive predictive value, by self-reported HIV infection status, of detecting hrHPV E6/E7 mRNA for the presence of CIN 2+ among women from two rural districts of Uganda participating in a community-based study of cervical cancer screening

From: Prevalence, correlates, and predictive value of high-risk human papillomavirus mRNA detection in a community-based cervical cancer screening program in western Uganda

hrHPV Type Detected

HIV-infectedb Participants

HIV-uninfected Participants

HIV-untested Participants

All Participants

Total No.

No. with CIN 2+

Positive predictive value % (95% CI)

Total No.

No. with CIN 2+

Positive predictive value % (95% CI)

Total No.

No. with CIN 2+

Positive predictive value % (95% CI)

Total No.

No. with CIN 2+

Positive predictive value% (95% CI)

Any hrHPV

42

4

9.8% (2.7 to 23%)

193

12

6.3% (3.3 to 11%)

20

5

25% (8.7 to 49%)

255

21

8.2% (5.1 to 12%)

At least one of HPV-16, 18 and 45a

10

1

10% (0.25 to 45%)

43

4

9.5% (2.7 to 23%)

5

4

80% (28 to 99%)

58

9

15% (7.3 to 27%)

HPV-16a

4

0

0% (0 to 60%)

28

3

11% (2.3 to 28%)

2

2

100% (16 to 100%)

34

5

15% (5.0 to 31%)

HPV-18 and/or 45a

7

1

14% (0.36 to 58%)

16

1

6.3% (0.15 to 30%)

3

2

67% (9.4 to 99%)

26

4

15% (4.4 to 35%)

At least one of HPV-31, 33, 35, 39, 51, 52, 56, 58, 59, 66 and 68 but without 16, 18 and 45

32

3

9.1% (1.9 to 24%)

150

8

29% (22 to 37%)

15

1

13% (1.7 to 40%)

197

12

6.1% (3.2 to 10%)

  1. amay also include HPV-31, 33, 35, 39, 51, 52, 56, 58, 59, 66 and 68
  2. bHIV infection status ascertained by self-report