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Table 3 Distribution of HLA-G allele, genotype and haplotype by disease status

From: Association of HLA-G 3′ UTR polymorphism and expression with the progression of cervical lesions in human papillomavirus 18 infections

  Control group HPV 18 group
  Normal CIN 1 CIN 2+
  40.8 ± 8.0 39.1 ± 8.9 40.5 ± 10.1 50.2 ± 12.3
Alleles n (%) n (%) OR(95% CI) n (%) OR(95% CI) n (%) OR(95% CI)
14 bp In/Del
  + 14 bp 108(29.2) 38(38.0) 1.48(0.94–2.36) 8(36.4) 1.39(0.57–3.39) 6(50.0) 2.43(0.79–7.45)
  − 14 bp 262(70.8) 62(62.0) 0.67(0.42–1.07) 14(63.6) 0.72(0.29–1.77) 6(50.0) 0.41(0.13–1.27)
 n 370 100   22   12  
+3142 C/G
 C 159(43.0) 23(23.0) 0.40(0.24–0.65) a 4(18.2) 0.29(0.10–0.84) b 4(33.3) 0.66(0.20–2.23)
 G 211(57.0) 77(77.0) 2.52(1.53–4.16) a 18(81.8) 3.39(1.19–9.65) b 8(66.7) 1.51(0.45–5.06)
 n 370 100   22   12  
Genotypes
14 bp In/Del
  + 14 bp/+ 14 bp 13(7.0) 5(10.0) 1.47(0.50–4.33) 1(9.1) 1.32(0.16–11.14) 2(33.3) 6.62(1.37–31.40) c
  + 14 bp/−14 bp 82(44.3) 28(56.0) 1.60(0.85–2.99) 6(54.5) 1.51(0.45–5.09) 3(50.0) 1.26(0.25–6.39)
  − 14 bp/−14 bp 90(48.7) 17(34.0) 0.54(0.28–1.04) 4(36.4) 0.60(0.17–2.11) 1(16.7) 0.21(0.03–1.53)
 n 185 50   11   6  
 + 3142 C/G        
 C/C 39(21.1) 1(2.0) 0.08(0.02–0.37) d 0(0.0) 0(0.00–0.00) 1(16.7) 0.75(0.09–6.59)
 C/G 81(43.8) 21(42.0) 0.93(0.49–1.75) 4(36.4) 0.73(0.21–2.59) 2(33.3) 0.64(0.12–3.56)
 G/G 65(35.1) 28(56.0) 2.35(1.26–4.40) e 7(63.6) 3.23(0.96–10.83) 3(50.0) 1.85(0.37–9.24)
 n 185 50   11   6  
Haplotypes
  + 14 bp /G 108(29.2) 38(38.0) 1.49(0.94–2.36) 8(36.4) 1.39(0.57–3.39) 6(50.0) 2.43(0.79–7.45)
  − 14 bp /G 103(27.8) 39(39.0) 1.66(1.05–2.62) f 10(45.5) 2.16(0.92–5.07) 2(16.7) 0.52(0.11–2.35)
  − 14 bp /C 159(43.0) 23(23.0) 0.40(0.24–0.65) g 4(18.1) 0.29(0.10–0.84) h 4(33.3) 0.66(0.20–2.23)
 n 370 100   22   12  
  1. Significant association are highlighted in bold
  2. CI confidence interval, OR odds ratio
  3. aχ2 = 13.23, P = 0.000
  4. bχ2 = 5.25, P = 0.022
  5. cχ2 = 5.53, P = 0.018
  6. dχ2 = 10.15, P = 0.001
  7. eχ2 = 7.17, P = 0.007
  8. fχ2 = 4.65, P = 0.031
  9. gχ2 = 13.23, P = 0.000
  10. hχ2 = 5.25, P = 0.022
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Infectious Agents and Cancer

ISSN: 1750-9378

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