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Table 3 Distribution of HLA-G allele, genotype and haplotype by disease status

From: Association of HLA-G 3′ UTR polymorphism and expression with the progression of cervical lesions in human papillomavirus 18 infections

 

Control group

HPV 18 group

 

Normal

CIN 1

CIN 2+

 

40.8 ± 8.0

39.1 ± 8.9

40.5 ± 10.1

50.2 ± 12.3

Alleles

n (%)

n (%)

OR(95% CI)

n (%)

OR(95% CI)

n (%)

OR(95% CI)

14 bp In/Del

  + 14 bp

108(29.2)

38(38.0)

1.48(0.94–2.36)

8(36.4)

1.39(0.57–3.39)

6(50.0)

2.43(0.79–7.45)

  − 14 bp

262(70.8)

62(62.0)

0.67(0.42–1.07)

14(63.6)

0.72(0.29–1.77)

6(50.0)

0.41(0.13–1.27)

n

370

100

 

22

 

12

 

+3142 C/G

 C

159(43.0)

23(23.0)

0.40(0.24–0.65) a

4(18.2)

0.29(0.10–0.84) b

4(33.3)

0.66(0.20–2.23)

 G

211(57.0)

77(77.0)

2.52(1.53–4.16) a

18(81.8)

3.39(1.19–9.65) b

8(66.7)

1.51(0.45–5.06)

n

370

100

 

22

 

12

 

Genotypes

14 bp In/Del

  + 14 bp/+ 14 bp

13(7.0)

5(10.0)

1.47(0.50–4.33)

1(9.1)

1.32(0.16–11.14)

2(33.3)

6.62(1.37–31.40) c

  + 14 bp/−14 bp

82(44.3)

28(56.0)

1.60(0.85–2.99)

6(54.5)

1.51(0.45–5.09)

3(50.0)

1.26(0.25–6.39)

  − 14 bp/−14 bp

90(48.7)

17(34.0)

0.54(0.28–1.04)

4(36.4)

0.60(0.17–2.11)

1(16.7)

0.21(0.03–1.53)

n

185

50

 

11

 

6

 

+ 3142 C/G

       

 C/C

39(21.1)

1(2.0)

0.08(0.02–0.37) d

0(0.0)

0(0.00–0.00)

1(16.7)

0.75(0.09–6.59)

 C/G

81(43.8)

21(42.0)

0.93(0.49–1.75)

4(36.4)

0.73(0.21–2.59)

2(33.3)

0.64(0.12–3.56)

 G/G

65(35.1)

28(56.0)

2.35(1.26–4.40) e

7(63.6)

3.23(0.96–10.83)

3(50.0)

1.85(0.37–9.24)

n

185

50

 

11

 

6

 

Haplotypes

  + 14 bp /G

108(29.2)

38(38.0)

1.49(0.94–2.36)

8(36.4)

1.39(0.57–3.39)

6(50.0)

2.43(0.79–7.45)

  − 14 bp /G

103(27.8)

39(39.0)

1.66(1.05–2.62) f

10(45.5)

2.16(0.92–5.07)

2(16.7)

0.52(0.11–2.35)

  − 14 bp /C

159(43.0)

23(23.0)

0.40(0.24–0.65) g

4(18.1)

0.29(0.10–0.84) h

4(33.3)

0.66(0.20–2.23)

n

370

100

 

22

 

12

 
  1. Significant association are highlighted in bold
  2. CI confidence interval, OR odds ratio
  3. aχ2 = 13.23, P = 0.000
  4. bχ2 = 5.25, P = 0.022
  5. cχ2 = 5.53, P = 0.018
  6. dχ2 = 10.15, P = 0.001
  7. eχ2 = 7.17, P = 0.007
  8. fχ2 = 4.65, P = 0.031
  9. gχ2 = 13.23, P = 0.000
  10. hχ2 = 5.25, P = 0.022