Control group | HPV 18 group | ||||||
---|---|---|---|---|---|---|---|
Normal | CIN 1 | CIN 2+ | |||||
40.8 ± 8.0 | 39.1 ± 8.9 | 40.5 ± 10.1 | 50.2 ± 12.3 | ||||
Alleles | n (%) | n (%) | OR(95% CI) | n (%) | OR(95% CI) | n (%) | OR(95% CI) |
14 bp In/Del | |||||||
+ 14 bp | 108(29.2) | 38(38.0) | 1.48(0.94–2.36) | 8(36.4) | 1.39(0.57–3.39) | 6(50.0) | 2.43(0.79–7.45) |
− 14 bp | 262(70.8) | 62(62.0) | 0.67(0.42–1.07) | 14(63.6) | 0.72(0.29–1.77) | 6(50.0) | 0.41(0.13–1.27) |
n | 370 | 100 | 22 | 12 | |||
+3142 C/G | |||||||
C | 159(43.0) | 23(23.0) | 0.40(0.24–0.65) a | 4(18.2) | 0.29(0.10–0.84) b | 4(33.3) | 0.66(0.20–2.23) |
G | 211(57.0) | 77(77.0) | 2.52(1.53–4.16) a | 18(81.8) | 3.39(1.19–9.65) b | 8(66.7) | 1.51(0.45–5.06) |
n | 370 | 100 | 22 | 12 | |||
Genotypes | |||||||
14 bp In/Del | |||||||
+ 14 bp/+ 14 bp | 13(7.0) | 5(10.0) | 1.47(0.50–4.33) | 1(9.1) | 1.32(0.16–11.14) | 2(33.3) | 6.62(1.37–31.40) c |
+ 14 bp/−14 bp | 82(44.3) | 28(56.0) | 1.60(0.85–2.99) | 6(54.5) | 1.51(0.45–5.09) | 3(50.0) | 1.26(0.25–6.39) |
− 14 bp/−14 bp | 90(48.7) | 17(34.0) | 0.54(0.28–1.04) | 4(36.4) | 0.60(0.17–2.11) | 1(16.7) | 0.21(0.03–1.53) |
n | 185 | 50 | 11 | 6 | |||
+ 3142 C/G | |||||||
C/C | 39(21.1) | 1(2.0) | 0.08(0.02–0.37) d | 0(0.0) | 0(0.00–0.00) | 1(16.7) | 0.75(0.09–6.59) |
C/G | 81(43.8) | 21(42.0) | 0.93(0.49–1.75) | 4(36.4) | 0.73(0.21–2.59) | 2(33.3) | 0.64(0.12–3.56) |
G/G | 65(35.1) | 28(56.0) | 2.35(1.26–4.40) e | 7(63.6) | 3.23(0.96–10.83) | 3(50.0) | 1.85(0.37–9.24) |
n | 185 | 50 | 11 | 6 | |||
Haplotypes | |||||||
+ 14 bp /G | 108(29.2) | 38(38.0) | 1.49(0.94–2.36) | 8(36.4) | 1.39(0.57–3.39) | 6(50.0) | 2.43(0.79–7.45) |
− 14 bp /G | 103(27.8) | 39(39.0) | 1.66(1.05–2.62) f | 10(45.5) | 2.16(0.92–5.07) | 2(16.7) | 0.52(0.11–2.35) |
− 14 bp /C | 159(43.0) | 23(23.0) | 0.40(0.24–0.65) g | 4(18.1) | 0.29(0.10–0.84) h | 4(33.3) | 0.66(0.20–2.23) |
n | 370 | 100 | 22 | 12 |