|
Control group
|
HPV 18 group
|
---|
|
Normal
|
CIN 1
|
CIN 2+
|
---|
|
40.8 ± 8.0
|
39.1 ± 8.9
|
40.5 ± 10.1
|
50.2 ± 12.3
|
---|
Alleles
|
n
(%)
|
n
(%)
|
OR(95% CI)
|
n
(%)
|
OR(95% CI)
|
n
(%)
|
OR(95% CI)
|
14 bp In/Del
|
+ 14 bp
|
108(29.2)
|
38(38.0)
|
1.48(0.94–2.36)
|
8(36.4)
|
1.39(0.57–3.39)
|
6(50.0)
|
2.43(0.79–7.45)
|
− 14 bp
|
262(70.8)
|
62(62.0)
|
0.67(0.42–1.07)
|
14(63.6)
|
0.72(0.29–1.77)
|
6(50.0)
|
0.41(0.13–1.27)
|
n
|
370
|
100
| |
22
| |
12
| |
+3142 C/G
|
C
|
159(43.0)
|
23(23.0)
|
0.40(0.24–0.65)
a
|
4(18.2)
|
0.29(0.10–0.84)
b
|
4(33.3)
|
0.66(0.20–2.23)
|
G
|
211(57.0)
|
77(77.0)
|
2.52(1.53–4.16)
a
|
18(81.8)
|
3.39(1.19–9.65)
b
|
8(66.7)
|
1.51(0.45–5.06)
|
n
|
370
|
100
| |
22
| |
12
| |
Genotypes
|
14 bp In/Del
|
+ 14 bp/+ 14 bp
|
13(7.0)
|
5(10.0)
|
1.47(0.50–4.33)
|
1(9.1)
|
1.32(0.16–11.14)
|
2(33.3)
|
6.62(1.37–31.40)
c
|
+ 14 bp/−14 bp
|
82(44.3)
|
28(56.0)
|
1.60(0.85–2.99)
|
6(54.5)
|
1.51(0.45–5.09)
|
3(50.0)
|
1.26(0.25–6.39)
|
− 14 bp/−14 bp
|
90(48.7)
|
17(34.0)
|
0.54(0.28–1.04)
|
4(36.4)
|
0.60(0.17–2.11)
|
1(16.7)
|
0.21(0.03–1.53)
|
n
|
185
|
50
| |
11
| |
6
| |
+ 3142 C/G
| | | | | | | |
C/C
|
39(21.1)
|
1(2.0)
|
0.08(0.02–0.37)
d
|
0(0.0)
|
0(0.00–0.00)
|
1(16.7)
|
0.75(0.09–6.59)
|
C/G
|
81(43.8)
|
21(42.0)
|
0.93(0.49–1.75)
|
4(36.4)
|
0.73(0.21–2.59)
|
2(33.3)
|
0.64(0.12–3.56)
|
G/G
|
65(35.1)
|
28(56.0)
|
2.35(1.26–4.40)
e
|
7(63.6)
|
3.23(0.96–10.83)
|
3(50.0)
|
1.85(0.37–9.24)
|
n
|
185
|
50
| |
11
| |
6
| |
Haplotypes
|
+ 14 bp /G
|
108(29.2)
|
38(38.0)
|
1.49(0.94–2.36)
|
8(36.4)
|
1.39(0.57–3.39)
|
6(50.0)
|
2.43(0.79–7.45)
|
− 14 bp /G
|
103(27.8)
|
39(39.0)
|
1.66(1.05–2.62)
f
|
10(45.5)
|
2.16(0.92–5.07)
|
2(16.7)
|
0.52(0.11–2.35)
|
− 14 bp /C
|
159(43.0)
|
23(23.0)
|
0.40(0.24–0.65)
g
|
4(18.1)
|
0.29(0.10–0.84)
h
|
4(33.3)
|
0.66(0.20–2.23)
|
n
|
370
|
100
| |
22
| |
12
| |
- Significant association are highlighted in bold
- CI confidence interval, OR odds ratio
- aχ2 = 13.23, P = 0.000
- bχ2 = 5.25, P = 0.022
- cχ2 = 5.53, P = 0.018
- dχ2 = 10.15, P = 0.001
- eχ2 = 7.17, P = 0.007
- fχ2 = 4.65, P = 0.031
- gχ2 = 13.23, P = 0.000
- hχ2 = 5.25, P = 0.022