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Table 2 Distribution of HLA-G allele, genotype and haplotype in controls and patients, stratified according to HPV type

From: Association of HLA-G 3′ UTR polymorphism and expression with the progression of cervical lesions in human papillomavirus 18 infections

 

Control group

Patient group

HPV 16 group

HPV 18 group

Alleles

n (%)

n (%)

OR(95% CI)

n (%)

OR(95% CI)

14 bp In/Del

In

108(29.2)

83(31.9)

1.14(0.81–1.60)

100(38.5)

1.52(1.08–2.12) a

Del

262(70.8)

177(68.1)

0.88(0.62–1.24)

160(61.5)

0.66(0.47–0.92) a

n

370

260

 

260

 

+3142 C/G

C

159(43.0)

109(41.9)

0.96(0.69–1.32)

71(27.3)

0.50(0.36–0.70) b

G

211(57.0)

151(58.1)

1.04(0.75–1.44)

189(72.7)

2.01(1.43–2.82) b

n

370

260

 

260

 

Genotypes

14 bp In/Del

In/In

13(7.0)

13(10.0)

1.47(0.66–3.28)

16(12.3)

1.86(0.87–3.98)

In/Del

82 (44.3)

57(43.8)

0.98(0.62–1.54)

68(52.3)

1.38(0.88–2.16)

Del/Del

90(48.7)

60(46.2)

0.90(0.57–1.42)

46(35.4)

0.58(0.36–0.92) c

n

185

130

 

130

 

+3142 C/G

C/C

39(21.1)

25(19.2)

0.89(0.51–1.56)

8(6.2)

0.25(0.12–0.52) d

C/G

81(43.8)

59(45.4)

1.07(0.68–1.68)

55(42.3)

0.94(0.60–1.48)

G/G

65(35.1)

46(35.4)

1.01(0.63–1.62)

67(51.5)

1.96(1.24–3.10) e

n

185

130

 

130

 

Haplotypes

In/G

108(29.2)

83(31.9)

1.14(0.81–1.60)

100(38.5)

1.52(1.08–2.12) f

Del/G

103(27.8)

68(26.2)

0.92(0.64–1.31)

89(34.2)

1.35(0.96–1.90)

Del/C

159(43.0)

109(41.9)

0.96(0.69–1.32)

71(27.3)

0.50(0.35–0.70) g

n

370

260

 

260

 
  1. Significant association is highlighted in bold
  2. CI confidence interval, OR odds ratio
  3. aχ2 = 5.94, P = 0.015
  4. bχ2 = 16.17, P = 0.000
  5. cχ2 = 5.48, P = 0.019
  6. dχ2 = 13.40, P = 0.000
  7. eχ2 = 8.44, P = 0.004
  8. fχ2 = 5.94, P = 0.015
  9. gχ2 = 16.17, P = 0.000