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Table 2 Distribution of HLA-G allele, genotype and haplotype in controls and patients, stratified according to HPV type

From: Association of HLA-G 3′ UTR polymorphism and expression with the progression of cervical lesions in human papillomavirus 18 infections

  Control group Patient group
HPV 16 group HPV 18 group
Alleles n (%) n (%) OR(95% CI) n (%) OR(95% CI)
14 bp In/Del
 In 108(29.2) 83(31.9) 1.14(0.81–1.60) 100(38.5) 1.52(1.08–2.12) a
 Del 262(70.8) 177(68.1) 0.88(0.62–1.24) 160(61.5) 0.66(0.47–0.92) a
 n 370 260   260  
+3142 C/G
 C 159(43.0) 109(41.9) 0.96(0.69–1.32) 71(27.3) 0.50(0.36–0.70) b
 G 211(57.0) 151(58.1) 1.04(0.75–1.44) 189(72.7) 2.01(1.43–2.82) b
 n 370 260   260  
Genotypes
14 bp In/Del
 In/In 13(7.0) 13(10.0) 1.47(0.66–3.28) 16(12.3) 1.86(0.87–3.98)
 In/Del 82 (44.3) 57(43.8) 0.98(0.62–1.54) 68(52.3) 1.38(0.88–2.16)
 Del/Del 90(48.7) 60(46.2) 0.90(0.57–1.42) 46(35.4) 0.58(0.36–0.92) c
 n 185 130   130  
+3142 C/G
 C/C 39(21.1) 25(19.2) 0.89(0.51–1.56) 8(6.2) 0.25(0.12–0.52) d
 C/G 81(43.8) 59(45.4) 1.07(0.68–1.68) 55(42.3) 0.94(0.60–1.48)
 G/G 65(35.1) 46(35.4) 1.01(0.63–1.62) 67(51.5) 1.96(1.24–3.10) e
 n 185 130   130  
Haplotypes
 In/G 108(29.2) 83(31.9) 1.14(0.81–1.60) 100(38.5) 1.52(1.08–2.12) f
 Del/G 103(27.8) 68(26.2) 0.92(0.64–1.31) 89(34.2) 1.35(0.96–1.90)
 Del/C 159(43.0) 109(41.9) 0.96(0.69–1.32) 71(27.3) 0.50(0.35–0.70) g
 n 370 260   260  
  1. Significant association is highlighted in bold
  2. CI confidence interval, OR odds ratio
  3. aχ2 = 5.94, P = 0.015
  4. bχ2 = 16.17, P = 0.000
  5. cχ2 = 5.48, P = 0.019
  6. dχ2 = 13.40, P = 0.000
  7. eχ2 = 8.44, P = 0.004
  8. fχ2 = 5.94, P = 0.015
  9. gχ2 = 16.17, P = 0.000
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Infectious Agents and Cancer

ISSN: 1750-9378

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