Table 4 Association between PIK3CA mutation status with main clinical-pathological features in the three groups
Variable | Â | PIK3CA gene | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Â | CM/ESCC group | Â | ESCC group | Â | CM group | Â | ||||
Category | WT | MUT | p-value | WT | MUT | p-value | WT | MUT | p-value | |
Alcohol consumption | No | 6 (35.3%) | 1 (20%) | 1.000** | 7 (21.2%) | 1 (20%) | 1.000** | 19 (70.4%) | 1 (100%) | 1.000** |
Yes | 11 (64.7%) | 4 (80%) | 26 (78.8%) | 4 (80%) | 8 (29.6%) | 0 (0%) | ||||
Tobacco consumption | No | 4 (23.5%) | 0 (0%) | 0.535** | 5 (15.2%) | 1 (20%) | 1.000** | 15 (100%) | 1 (100%) | 1.000** |
Yes | 13 (76.5%) | 5 (100%) | 28 (84.8%) | 4 (80%) | 12 (44.4%) | 0 (0%) | ||||
Tumor differentiation | Well | 4 (22.2%) | 1 (25%) | 1.000** | 7 (22.6%) | 0 (0%) | 0.171** | NA | NA | NA |
Moderate | 13 (72.2%) | 3 (75%) | 21 (67.7%) | 3 (60%) | NA | NA | ||||
Poorly | 1 (5.6%) | 0 (0%) | 3 (9.7%) | 2 (40%) | NA | NA | ||||
TNM Staging | I e II | 4 (28.6%) | 0 (0%) | 0.541** | 15 (46.9%) | 1 (20%) | 0.421** | NA | NA | NA |
III e IV | 10 (71.4%) | 3 (100%) | 17 (53.1%) | 4 (80%) | NA | NA | ||||
Megaesophagus degree | GI/GII | 7 (41.2%) | 3 (60%) | 0.406** | NA | NA | NA | 3 (11.1%) | 1 (100%) | 0.143** |
GIII/GIV | 10 (58.8%) | 2 (40%) | NA | NA | 24 (88.9%) | 0 (0%) | ||||
TP53 gene [7] | WT | 9 (50%) | 2 (40%) | 1.000** | 20 (60.6%) | 2 (40%) | 0.632** | 26 (96.3%) | 1 (100%) | 1.000** |
MUT | 9 (50%) | 3 (60%) | 13 (39.4%) | 3 (60%) | 1 (3.7%) | 0 (0%) | ||||