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Table 4 Association between PIK3CA mutation status with main clinical-pathological features in the three groups

From: PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Variable   PIK3CA gene
  CM/ESCC group   ESCC group   CM group  
Category WT MUT p-value WT MUT p-value WT MUT p-value
Alcohol consumption No 6 (35.3%) 1 (20%) 1.000** 7 (21.2%) 1 (20%) 1.000** 19 (70.4%) 1 (100%) 1.000**
Yes 11 (64.7%) 4 (80%) 26 (78.8%) 4 (80%) 8 (29.6%) 0 (0%)
Tobacco consumption No 4 (23.5%) 0 (0%) 0.535** 5 (15.2%) 1 (20%) 1.000** 15 (100%) 1 (100%) 1.000**
Yes 13 (76.5%) 5 (100%) 28 (84.8%) 4 (80%) 12 (44.4%) 0 (0%)
Tumor differentiation Well 4 (22.2%) 1 (25%) 1.000** 7 (22.6%) 0 (0%) 0.171** NA NA NA
Moderate 13 (72.2%) 3 (75%) 21 (67.7%) 3 (60%) NA NA
Poorly 1 (5.6%) 0 (0%) 3 (9.7%) 2 (40%) NA NA
TNM Staging I e II 4 (28.6%) 0 (0%) 0.541** 15 (46.9%) 1 (20%) 0.421** NA NA NA
III e IV 10 (71.4%) 3 (100%) 17 (53.1%) 4 (80%) NA NA
Megaesophagus degree GI/GII 7 (41.2%) 3 (60%) 0.406** NA NA NA 3 (11.1%) 1 (100%) 0.143**
GIII/GIV 10 (58.8%) 2 (40%) NA NA 24 (88.9%) 0 (0%)
TP53 gene [7] WT 9 (50%) 2 (40%) 1.000** 20 (60.6%) 2 (40%) 0.632** 26 (96.3%) 1 (100%) 1.000**
MUT 9 (50%) 3 (60%) 13 (39.4%) 3 (60%) 1 (3.7%) 0 (0%)
  1. **Fisher’s exact test; ***Analysis of variance. CME/ESCC – chagasic megaesophagus associated with esophageal squamous cell carcinoma; ESCC – esophageal squamous cell carcinoma without chagasic megaesophagus; CME – chagasic megaesophagus without esophageal squamous cell carcinoma. N – number of cases; SD – standard deviation; NA – not applicable; WT – wild-type; MUT – mutated