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Table 3 Profile of oncogenic PIK3CA mutations in the three study groups

From: PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Group Sample ID Exon Codon Codon (WT – MUT) Type of mutation Amino acids change Nature of mutation COSMIC ID
CM/ESCC 111 T 9 545 GAG – GCA A → C E545A Missense COSM12458
122 T 9 549 GAT – CAT G → C D549H Missense COSM219119
114 T 20 1027 GCC – GAC C → A A1027D Missense Not reported
119 T 20 1047 CAT – CTT A → T H1047L Missense COSM776
124 T 20 1047 CAT–CGT A → G H1047R Missense COSM775
ESCC 26 T 9 545 GAG – GCG A → C E545A Missense COSM12458
120 T 9 555 AGG – AAG G → A R555K Missense COSM1716158
36 T 9 524 AGG – AAG G → A R524K Missense COSM53245
4 T 20 1030 AAA – AGA A → G K1030R Missense Not reported
CME 101 M 20 1053 ACA – AAA C → A T1053K Missense Not reported
  1. CME/ESCC – chagasic megaesophagus associated with esophageal squamous cell carcinoma; ESCC – esophageal squamous cell carcinoma without chagasic megaesophagus; CME – chagasic megaesophagus without esophageal squamous cell carcinoma. A – adenine; C – cytosine; G – guanine; T – thymine. WT – wild-type; MUT – mutant