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Table 3 Profile of oncogenic PIK3CA mutations in the three study groups

From: PIK3CA mutations are frequent in esophageal squamous cell carcinoma associated with chagasic megaesophagus and are associated with a worse patient outcome

Group

Sample ID

Exon

Codon

Codon (WT – MUT)

Type of mutation

Amino acids change

Nature of mutation

COSMIC ID

CM/ESCC

111 T

9

545

GAG – GCA

A → C

E545A

Missense

COSM12458

122 T

9

549

GAT – CAT

G → C

D549H

Missense

COSM219119

114 T

20

1027

GCC – GAC

C → A

A1027D

Missense

Not reported

119 T

20

1047

CAT – CTT

A → T

H1047L

Missense

COSM776

124 T

20

1047

CAT–CGT

A → G

H1047R

Missense

COSM775

ESCC

26 T

9

545

GAG – GCG

A → C

E545A

Missense

COSM12458

120 T

9

555

AGG – AAG

G → A

R555K

Missense

COSM1716158

36 T

9

524

AGG – AAG

G → A

R524K

Missense

COSM53245

4 T

20

1030

AAA – AGA

A → G

K1030R

Missense

Not reported

CME

101 M

20

1053

ACA – AAA

C → A

T1053K

Missense

Not reported

  1. CME/ESCC – chagasic megaesophagus associated with esophageal squamous cell carcinoma; ESCC – esophageal squamous cell carcinoma without chagasic megaesophagus; CME – chagasic megaesophagus without esophageal squamous cell carcinoma. A – adenine; C – cytosine; G – guanine; T – thymine. WT – wild-type; MUT – mutant