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Table 3 Glycogenes downregulated in HeLa shE6/E7 cells

From: Glycogene expression profiles based on microarray data from cervical carcinoma HeLa cells with partially silenced E6 and E7 HPV oncogenes

Gene/enzyme Enzyme function Gene alteration in cancer and oncogenic- associated-effects
PIGV
Phosphatidylinositol Glycan Anchor Biosynthesis Class V
Transfers the second mannose in the glycosylphosphatidylinositol (GPI) anchor Not reported
GALNT1
Polypeptide N-Acetylgalactosaminyltransferase 1
Transfers N-acetylgalactosamine (GalNAc) to a serine or threonine residue O-glycosylation mRNA upregulated in bladder cancer stem cells [57]
C1GALT1C1
C1GALT1 Specific Chaperone 1
Specific chaperone assisting the folding/stability of C1GALT1, for the generation of core 1 O-glycan T antigen mRNA and protein upregulated in colorectal cancer [27]
FCMD
Fukutin
Glycosyltransferase involved in the biosynthesis of α-dystroglycan (α-DG) Not reported
MANBAL
Mannosidase, beta A, lysosomal-like
Mannosidase beta-like Not reported
B4GALT2
Beta-1,4-Galactosyltransferase 2
Transfers galactose to the terminal N-acetylglucosamine of complex-type N-glycans Missense mutations in B4GALT2 gene in colon cancer with a predictive deleterious phenotype [58]
UGT8
Ceramide UDP-Galactosyltransferase
Catalyzes the transfer of galactose to ceramide (biosynthesis of GalCer) mRNA and protein upregulated in breast [28] and increased protein expression in lung cancer [59]
  1. Table showing downregulated glycogenes, the names of the coded enzymes and their alteration in different cancer types