Table 3 Glycogenes downregulated in HeLa shE6/E7 cells
Gene/enzyme | Enzyme function | Gene alteration in cancer and oncogenic- associated-effects |
|---|---|---|
PIGV Phosphatidylinositol Glycan Anchor Biosynthesis Class V | Transfers the second mannose in the glycosylphosphatidylinositol (GPI) anchor | Not reported |
GALNT1 Polypeptide N-Acetylgalactosaminyltransferase 1 | Transfers N-acetylgalactosamine (GalNAc) to a serine or threonine residue O-glycosylation | mRNA upregulated in bladder cancer stem cells [57] |
C1GALT1C1 C1GALT1 Specific Chaperone 1 | Specific chaperone assisting the folding/stability of C1GALT1, for the generation of core 1 O-glycan T antigen | mRNA and protein upregulated in colorectal cancer [27] |
FCMD Fukutin | Glycosyltransferase involved in the biosynthesis of α-dystroglycan (α-DG) | Not reported |
MANBAL Mannosidase, beta A, lysosomal-like | Mannosidase beta-like | Not reported |
B4GALT2 Beta-1,4-Galactosyltransferase 2 | Transfers galactose to the terminal N-acetylglucosamine of complex-type N-glycans | Missense mutations in B4GALT2 gene in colon cancer with a predictive deleterious phenotype [58] |
UGT8 Ceramide UDP-Galactosyltransferase | Catalyzes the transfer of galactose to ceramide (biosynthesis of GalCer) | mRNA and protein upregulated in breast [28] and increased protein expression in lung cancer [59] |