Skip to main content

Advertisement

Table 2 Glycogenes upregulated in HeLa shE6/E7 cells

From: Glycogene expression profiles based on microarray data from cervical carcinoma HeLa cells with partially silenced E6 and E7 HPV oncogenes

Gene/enzyme Enzyme function Gene alteration in cancer and oncogenic associated-effects
ALG14
UDP-N-Acetylglucosaminyltransferase Subunit
Associates with ALG13 and transfers a GlcNAc on GlcNAc-PP-Dol (second step of N-linked glycosylation) Not reported
FUT4
Fucosyltransferase 4
Catalyzes the transfer of fucose (Fuc) residues from GDP-Fuc to [Fucα1 → 2Galβ1 → 4GlcNAcβ1 → R] in α-1, 3 linkage mRNA upregulated in acute myeloid leukaemia [54], gastric [30] and colorectal cancers [32].
Protein upregulated in breast cancer was associated with proliferation and metastasis [31]
MAN2A1
Mannosidase Alpha Class 2A Member 1
Hydrolyzes two peripheral mannosyl residues from Manαl--6(Manαl--3) Manαl--6(GlcNAcβ1--2Manα1--3) [Manβ1--4GlcNAcβ1--4GlcNAcβ1]- asparagine structure MAN2A1– FER tyrosine kinase fusion gene is expressed in liver tumours, oesophageal adenocarcinoma, glioblastoma multiforme, prostate tumours, non-small cell lung tumours, and ovarian tumours [55].
DPY19L1
Dpy19 like 1 (C. elegans)
Participates in the C-mannosylation of tryptophan residues on target proteins. Not reported
C3orf21 (XXYLT1)
Xyloside Xylosyltransferase 1
Elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats (Notch proteins) by catalyzing the addition of the second xylose Lower frequency of wild type genotype in the C3orf21 gene rs 2,131,877 locus in lung adenocarcinoma tissues [56]
IDUA
Iduronidase, Alpha-L-
Cleaves α-linked iduronic acid residues from the nonreducing end of the glycosaminoglycans (GAGs), heparan sulfate, and dermatan sulfate Not reported
UGT2B17
UDP Glucuronosyltransferase Family 2 Member B17
Catalyzes the glucuronidation of steroids (detoxification) mRNA upregulated in endometrial cancer [33]
POFUT1
Protein O-Fucosyltransferase 1
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine of EGF domains mRNA upregulated in glioblastomas [26]
Protein upregulated in oral squamous cell carcinoma [29]
UGCGL1
UDP-Glucose Glycoprotein Glucosyltransferase 1
Reglucosylates single N-glycans near the misfolded part of the protein Not reported
  1. Table showing upregulated glycogenes, the names of the coded enzymes, their alteration in different cancer types and their oncogenic-associated-effects