Table 2 Glycogenes upregulated in HeLa shE6/E7 cells

ALG14

UDP-N-Acetylglucosaminyltransferase Subunit

Associates with ALG13 and transfers a GlcNAc on GlcNAc-PP-Dol (second step of N-linked glycosylation)

Not reported

FUT4

Fucosyltransferase 4

Catalyzes the transfer of fucose (Fuc) residues from GDP-Fuc to [Fucα1 → 2Galβ1 → 4GlcNAcβ1 → R] in α-1, 3 linkage

mRNA upregulated in acute myeloid leukaemia [54], gastric [30] and colorectal cancers [32].

Protein upregulated in breast cancer was associated with proliferation and metastasis [31]

MAN2A1

Mannosidase Alpha Class 2A Member 1

Hydrolyzes two peripheral mannosyl residues from Manαl--6(Manαl--3) Manαl--6(GlcNAcβ1--2Manα1--3) [Manβ1--4GlcNAcβ1--4GlcNAcβ1]- asparagine structure

MAN2A1– FER tyrosine kinase fusion gene is expressed in liver tumours, oesophageal adenocarcinoma, glioblastoma multiforme, prostate tumours, non-small cell lung tumours, and ovarian tumours [55].

DPY19L1

Dpy19 like 1 (C. elegans)

Participates in the C-mannosylation of tryptophan residues on target proteins.

Not reported

C3orf21 (XXYLT1)

Xyloside Xylosyltransferase 1

Elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats (Notch proteins) by catalyzing the addition of the second xylose

Lower frequency of wild type genotype in the C3orf21 gene rs 2,131,877 locus in lung adenocarcinoma tissues [56]

IDUA

Iduronidase, Alpha-L-

Cleaves α-linked iduronic acid residues from the nonreducing end of the glycosaminoglycans (GAGs), heparan sulfate, and dermatan sulfate

Not reported

UGT2B17

UDP Glucuronosyltransferase Family 2 Member B17

Catalyzes the glucuronidation of steroids (detoxification)

mRNA upregulated in endometrial cancer [33]

POFUT1

Protein O-Fucosyltransferase 1

Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine of EGF domains

mRNA upregulated in glioblastomas [26]

Protein upregulated in oral squamous cell carcinoma [29]

UGCGL1

UDP-Glucose Glycoprotein Glucosyltransferase 1

Reglucosylates single N-glycans near the misfolded part of the protein

Not reported