Table 5 Univariate and multivariate analysis of factors associated with overall survival
From: Prognostic factors in patients with HBV-related hepatocellular carcinoma following hepatic resection
| Â | Univariate | Multivariate | ||
|---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Gender (male) | ||||
 female | 0.552 (0.28–1.07) | 0.080 |  |  |
Age (years) | 1.002 (0.96–1.04) | 0.890 |  |  |
HCV (no) | ||||
 yes | – |  |  |  |
Platelets × 103 (mm3) | 0.999 (0.99–1.01) | 0.829 |  |  |
AFP-pre (ng/mL) | 1.011 (0.99–1.03) | 0.300 |  |  |
AFP-post (ng/mL) | 1.218 (1.10–1.35) | 0.000 | 1.206 (1.08–1.34) | 0.000 |
Tumor size (< 5 cm) | 1.052 (0.99–1.12) | 0.091 |  |  |
  ≥ 5 cm. | 1.679 (1.01–2.77) | 0.044 |  |  |
Number of tumors (solitary) | ||||
 multiple | 2.300 (1.18–4.47) | 0.014 | 2.715 (1.05–7.02) | 0.039 |
Microvascular invasion (no) | ||||
 yes | 1.598 (0.72–3.54) | 0.249 |  |  |
Stage (I) | ||||
 II or higher | 0.737 (0.35–1.53) | 0.415 |  |  |
Resection margin (free margin) | ||||
 positive margin | 2.140 (0.65–7.05) | 0.211 |  |  |
Operation type (anatomical) | ||||
 non-anatomical | 0.409 (0.21–0.78) | 0.007 |  |  |
Preoperative neoadjuvant (no) | ||||
 yes | 0.958 (0.45–2.01) | 0.910 |  |  |
Platelet-to-lymphocyte ratio | 1.003 (0.99–1.01) | 0.195 |  |  |
Prognostic nutritional index | 0.991 (0.98–1.00) | 0.065 |  |  |
Neutrophil-to-lymphocyte ratio | 1.070 (0.82–1.39) | 0.621 |  |  |
Antiviral treatment | ||||
 no | 0.482 (0.25–0.92) | 0.027 |  |  |
Antiplatelet treatment (ASA + Clopidogrel) | ||||
 no | 1.542 (0.37–6.41) | 0.551 |  |  |
Recurrence (no) | ||||
 yes | 2.940 (1.42–6.05) | 0.003 | 12.824 (1.68–97.86) | 0.014 |