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Table 3 Univariate and multivariate analysis of factors associated with recurrence

From: Prognostic factors in patients with HBV-related hepatocellular carcinoma following hepatic resection

 

Univariate

Multivariate

HR (95% CI)

P value

HR (95% CI)

P value

Gender (male)

 female

0.894 (0.60–1.32)

0.574

  

Age (years)

0.996 (0.97–1.02)

0.719

  

HCV (no)

 yes

1.473 (0.59–3.62)

0.399

  

Platelets × 103 (mm3)

0.987 (0.96–1.01)

0.367

  

AFP-pre (ng/mL)

0.996 (0.97–1.01)

0.665

  

AFP-post (ng/mL)

1.112 (1.02–1.21)

0.012

1.129 (1.04–1.23)

0.005

Tumor size (< 5 cm)

1.061 (1.01–1.11)

0.013

  

  ≥ 5 cm

1.345 (0.90–1.99)

0.139

  

Number of tumors (solitary)

 multiple

1.881 (1.23–2.86)

0.003

1.973 (1.15–3.38)

0.013

Microvascular invasion (no)

 yes

1.645 (1.02–2.63)

0.037

  

Stage (I)

 II or higher

1.553 (1.04–2.31)

0.031

  

Resection margin (free margin)

 positive margin

0.977 (0.35–2.66)

0.964

  

Operation type (anatomical)

 non-anatomical

0.708 (0.47–1.05)

0.085

  

Preoperative neoadjuvant (no)

 yes

0.828 (0.51–1.34)

0.450

  

Platelet-to-lymphocyte ratio

0.913 (0.61–1.34)

0.648

  

Prognostic nutritional index

0.959 (0.56–1.61)

0.875

  

Neutrophil-to-lymphocyte ratio

1.052 (0.89–1.23)

0.535

  

Antiviral treatment

 no

1.519 (1.01–2.28)

0.045

1.823 (1.07–3.09)

0.026

Antiplatelet treatment (ASA + Clopidogrel)

 no

1.018 (0.49–2.09)

0.961

  
  1.  AFP alpha-fetoprotein, ASA aspirin, CI confidence interval, HR hazard ratio, HCV hepatitis C virus
  2. NOTE. Italic font indicates statistical significance