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Table 4 Number of annual cases of each lesion attributable to HPV genotypes targeted by the 4-valent and 9-valent vaccines and associated costs

From: Epidemiologic and economic burden of HPV diseases in Spain: implication of additional 5 types from the 9-valent vaccine

Lesion

Cases attributable to HPV 6/11/16/18 and associated costs

Cases attributable to HPV 6/11/16/18/31/33/45/52/58 and associated costs

Cases attributable to HPV 31/33/45/52/58 and associated costs (a)

Number of annual cases

Costs (€ 2017)

Number of annual cases

Costs (€ 2017)

Number of annual cases

Costs (€ 2017)

Genital warts (b)

49,251

51.04 Mill €

49,251

51.04 Mill €

0

0.00 Mill €

CIN 2/3

15,285

35.50 Mill €

27,648

64.22 Mill €

12,363

28.72 Mill €

VIN2/3

1001

3.93 Mill €

1162

4.56 Mill €

161

0.63 Mill €

VaIN 2/3

155

0.55 Mill €

186

0.66 Mill €

31

0.11 Mill €

AIN 2/3 (b)

149

0.59 Mill €

162

0.65 Mill €

13

0.05 Mill €

PIN 2/3

218

0.59 Mill €

247

0.67 Mill €

29

0.08 Mill €

Cervical cancer (c)

1730

15.15 Mill €

2110

18.48 Mill €

380

3.33 Mill €

Vulvar cancer (d)

94

1.22 Mill €

110

1.43 Mill €

16

0.21 Mill €

Vaginal cancer (c)

50

0.54 Mill €

66

0.71 Mill €

16

0.17 Mill €

Anal cancer (b)(c)(e)

264

2.02 Mill €

289

2.21 Mill €

25

0.19 Mill €

Penile cancer (c)(e)

98

0.70 Mill €

111

0.79 Mill €

13

0.09 Mill €

Oral cavity (b)(c)(e)

131

1.03 Mill €

147

1.15 Mill €

16

0.12 Mill €

Nasopharynx (b)(c)(e)

27

0.21 Mill €

32

0.25 Mill €

5

0.04 Mill €

Oropharynx cancer (b)(c)(e)

258

1.94 Mill €

272

2.05 Mill €

14

0.10 Mill €

Hypopharynx (b)(c)(e)

28

0.23 Mill €

34

0.28 Mill €

6

0.05 Mill €

Pharynx cancer (b)(c)(e)

39

0.30 Mill €

39

0.30 Mill €

0

0.00 Mill €

Larynx cancer (b)(c)(e)

132

1.15 Mill €

171

1.49 Mill €

39

0.34 Mill €

TOTAL

68,910

116.7 Mill €

82,038

150.9 Mill €

13,128

34.24 Mill €

  1. (a) Difference between the number of cases of each lesion attributable to the genotypes targeted by the 9-valent and 4-valent vaccines and associated costs
  2. (b) Includes both men and women
  3. (c) Genotypes 6 and 11 not included
  4. (d) HPV attributable fraction estimated on HPV DNA and p16 positivity
  5. (e) Only hospitalization costs were considered
  6. AIN anal intraepithelial neoplasia; CIN cervical intraepithelial neoplasia; HPV human papillomavirus; mill.: million; PIN penile intraepithelial neoplasia; VaIN vaginal intraepithelial neoplasia; VIN vulvar intraepithelial neoplasia