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Table 3 Direct costs of the management of each type on lesion in Spain reported in the literature and use of resources considered

From: Epidemiologic and economic burden of HPV diseases in Spain: implication of additional 5 types from the 9-valent vaccine

Lesion [sources] Cost (2017 €) Use of resources
Genital warts [11] 1036€ Visits with specialists, diagnosis tests, pharmacological and other treatments and hospitalizations.
CIN 2/3 [14] CIN2:2022€ Visits with gynecologists, diagnosis tests, pharmacological, laser and surgical treatments, and medical complications.
CIN 3: 2600€
Cervical cancer [27] 8760€ Diagnosis (colposcopy, cytology, HPV DNA testing), treatment (LEEP/LLETZ, hysterectomy, conization, laser destruction, radiotherapy and chemotherapy)
Vulvar cancer [28] 12,994€ Direct cost of diagnosis, treatment and hospitalization
Vaginal cancer [28] 10,664€
Anal cancer (men) [29] 7790€ Direct costs of hospitalized patients based on Diagnosis-related groups
Anal cancer (women) [29] 7481€
Penile cancer [29] 7135€
Oral cavity cancer (men) [30] 7984€
Oral cavity cancer (women) [30] 8198€
Nasopharynx cancer (men) [30] 8086€
Nasopharynx cancer (women) [30] 6708€
Oropharynx cancer (other) (men) [30] 7373€
Oropharynx cancer (other) (women) [30] 7462€
Hypopharynx cancer (men) [30] 8213€
Hypopharynx cancer (women) [30] 7838€
Pharynx cancer (men) [30] 7478€
Pharynx cancer (women) [30] 8618€
Larynx cancer (men) [30] 8652€
Larynx cancer (women) [30] 9257€
  1. CIN: cervical intraepithelial neoplasia; DNA: deoxyribonucleic acid; HPV: human papillomavirus; LEEP: loop electrosurgical excision procedure; LLETZ: large loop excision on the transformation zone