Epidemiologic and economic burden of HPV diseases in Spain: implication of additional 5 types from the 9-valent vaccine

Table 2 Crude incidence rates and estimated number of new annual cases of genital warts, precancerous lesions and cancer in men and women in Spain

Lesion [sources]	ICD-10	Crude annual incidence rate per 100.000 men or women	Estimated number of new annual cases in 2016 in Spain (95% CI)
Genital warts (men) [11]	NA	136.60	31,163 (30,806–31,497)
Genital warts (women) [11]	NA	99.60	23,560 (23,238–23,839)
CIN 2/3 [13,15]	NA	142.02	33,594 (33,235–33,953)
VIN2/3 [13,15]	NA	6.02	1424 (1350–1498)
VaIN 2/3 [13,15]	NA	1.02	241 (210–271)
AIN 2/3 (men) [13, 16]	NA	0.57	130 (108–153)
AIN 2/3 (women) [13, 16]	NA	0.27	63 (47–78)
PIN 2/3 [13, 17]	NA	1.32	302 (268–336)
Cervical cancer [13]	C53	10.10	2389 (2293–2485)
Vulvar cancer [12, 13]	C51	2.77	655 (556–754)
Vaginal cancer [12, 13]	C52	0.47	111 (70–151)
Anal cancer (men) [12, 13]	C21	0.86	197 (143–250)
Anal cancer (women) [12, 13]	C21	0.68	160 (111–209)
Penile cancer [12, 13]	C60	1.91	436 (356–516)
Oral cavity cancer (men) [12, 13]	C02–06	7.55	1724 (1492–1955)
Oral cavity cancer (women) [12, 13]	C02–06	0.64	736 (574–876)
Nasopharynx cancer (men) [12, 13]	C11	1.54	352 (277–426)
Nasopharynx cancer (women) [12, 13]	C11	0.45	106 (65–148)
Oropharynx cancer (men) [12, 13]	C01, C09, C10	1.64	1066 (841–1290)
Oropharynx cancer (women) [12, 13]	C01, C09, C10	0.10	152 (68–233)
Hypopharynx cancer (men) [12, 13]	C12–13	3.62	826 (711–940)
Hypopharynx cancer (women) [12, 13]	C12–13	0.25	59 (28–89)
Pharynx cancer (men) [12, 13]	C14	1.05	240 (179–302)
Pharynx cancer (women) [12, 13]	C14	0.13	32 (9–54)
Larynx cancer (men) [12, 13]	C32	16.72	3815 (3569–4060)
Larynx cancer (women) [12, 13]	C32	0.92	217 (158–276)

95% CI: 95% confidence interval; NA: not applicable; AIN: anal intraepithelial neoplasia; CIN: cervical intraepithelial neoplasia; HPV: human papillomavirus; ICD: International Classification of Diseases; PIN: penile intraepithelial neoplasia; VaIN: vaginal intraepithelial neoplasia; VIN: vulvar intraepithelial neoplasia

ISSN: 1750-9378