Table 2 Evidences for carcinogenic and non-carcinogenic role of BKPyV
Evidences of BKPyV carcinogenicity | Evidences for a non-carcinogenic role |
|---|---|
Viral oncogenes are expressed in tumors | Poor and not efficient transforming activity in human cells |
Tumors developed in in vivo models | Ubiquitous distribution in normal human cells and tissues |
Transforming properties in in vitro models | Variable BKPyV presence in tumors among different studies |
BKPyV alterations occur before immortalization | |
BKPyV genome detected in human tumors | |