Table 1 Function of BKPyV gene products
BKPyV expression products | Function | |
|---|---|---|
Early | Large Tumour Antigen (Tag) | Cell cycle progression, inhibition of apoptosis, viral replication |
truncated Large T antigen (truncTAg) | Cell cycle progression, viral replication | |
Minor T Antigen (tAg) | Cell cycle progression | |
3p-miRNA | viral persistence | |
5p-miRNA | viral persistence | |
Late | VP1 | capsid structure (external), viral attachment and entry |
VP2 | capsid structure (internal), involved in viral infectivity | |
VP3 | capsid structure (internal), involved in viral infectivity | |
Agno protein | Life cycle (assembly, maturation, release) |