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Table 3 The frequencies of specific amino acid mutations associated with the major and minor population of HBV quasispecies

From: Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection

Region Position HBsAg positive (n = 10) OBI (n = 9) P value
Major population
S I126S/T 30 0 0.040
Y200F/S 0 33.3 0.025
Y206C/H/S 30 0 0.040
Minor population
Pre-S W4R 0 33.3 0.025
S5A/P/T 30 0 0.040
L30S 10 77.8 0.001
G35R 30 0 0.040
H51P/R 30 0 0.040
E54K 50 0 0.006
A60V 30 0 0.040
W77R/Stop 30 0 0.040
I84T 60 11.1 0.014
N98 K/T 30 0 0.040
G102R 30 0 0.040
Q118R/Stop 0 44.4 0.008
N123D 10 44.4 0.049
S124F/P 0 33.3 0.025
S L21F/S 70 100 0.040
L42F/S 0 33.3 0.025
W182Stop 30 0 0.040
L213F/I/T 40 0 0.017
  1. Bold indicated the amino acid position which mutational frequencies in OBI were higher than those in HBsAg positive