|
Region
|
Position
|
HBsAg positive (n = 10)
|
OBI (n = 9)
|
P value
|
|---|
|
Major population
|
|
S
|
I126S/T
|
30
|
0
|
0.040
|
|
Y200F/S
|
0
|
33.3
|
0.025
|
|
Y206C/H/S
|
30
|
0
|
0.040
|
|
Minor population
|
|
Pre-S
|
W4R
|
0
|
33.3
|
0.025
|
|
S5A/P/T
|
30
|
0
|
0.040
|
|
L30S
|
10
|
77.8
|
0.001
|
|
G35R
|
30
|
0
|
0.040
|
|
H51P/R
|
30
|
0
|
0.040
|
|
E54K
|
50
|
0
|
0.006
|
|
A60V
|
30
|
0
|
0.040
|
|
W77R/Stop
|
30
|
0
|
0.040
|
|
I84T
|
60
|
11.1
|
0.014
|
|
N98 K/T
|
30
|
0
|
0.040
|
|
G102R
|
30
|
0
|
0.040
|
|
Q118R/Stop
|
0
|
44.4
|
0.008
|
|
N123D
|
10
|
44.4
|
0.049
|
|
S124F/P
|
0
|
33.3
|
0.025
|
|
S
|
L21F/S
|
70
|
100
|
0.040
|
|
L42F/S
|
0
|
33.3
|
0.025
|
|
W182Stop
|
30
|
0
|
0.040
|
|
L213F/I/T
|
40
|
0
|
0.017
|
- Bold indicated the amino acid position which mutational frequencies in OBI were higher than those in HBsAg positive
