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Table 2 Amino acid mutations in the pre-S/S region of the major quasispecies populations

From: Quasispecies variant of pre-S/S gene in HBV-related hepatocellular carcinoma with HBs antigen positive and occult infection

Domain AA Position (number) HBsAg
Positive (%)
OBI
(%)
P
PreS1 aa1–119 (119) 2.80 ± 1.69 4.22 ± 3.31 0.12
 NTCP aa2–48 (47) 0.60 ± 0.84 0.33 ± 0.50 0.21
 HSP70 aa74–118 (45) 0.60 ± 0.70 0.33 ± 0.50 0.18
 S promoter aa66–111 (46) 0.70 ± 0.67 0.33 ± 0.50 0.10
 NBS aa103–127 (25) 0.20 ± 0.63 0.56 ± 0.88 0.16
 T cell epitope aa21–30,52–67 (26) 0.50 ± 0.71 0.67 ± 0.87 0.33
 B cell epitope aa12–47,72–78,94–117 (67) 0.70 ± 0.82 0.00 ± 0.00 0.01*
S aa1-227 (227) 8.10 ± 8.62 7.33 ± 4.74 0.41
 Pre-a determinant aa100–119 (20) 1.20 ± 0.79 1.11 ± 0.33 0.38
 a determinant aa 124–148 (25) 0.70 ± 0.82 0.00 ± 0.00 0.01*
 Post a determinant aa 149–169 (21) 0.30 ± 0.67 0.22 ± 0.67 0.40
 HLA class I aa87–98, 186–197, 215–223 (29) 1.80 ± 1.81 1.44 ± 0.73 0.29
 HLA class II aa97–106, 171–179, 206–215 (29) 0.50 ± 0.85 0.44 ± 0.73 0.44
  1. *P < 0.05