Skip to main content

Table 2 Detection of EBV genome in breast cancer samples by PCR using EBER and LMP-1 primers

From: Association of Epstein - Barr virus and breast cancer in Eritrea

Primer Breast cancer cases

 

Noncancerous cases

p-Val*

EBER

 Positive

33

4

0.0031*

 Negative

111

59

 

LMP1

 Positive

14

2

0.1563

 Negative

130

61

 
  1. Amplification fragments of both EBER and LMP1 of EBV were detected using PCR. A total of 40 (27.77%) of 144 breast cancer samples showed faint bands compared to the band formed by the positive control from a case of nasopharyngeal carcinoma by either of the markers. Of this faint band 33(22.91%) were revealed using EBER and14 (9.72%) using LMP1and 7(4.86%) were positive by both markers. Out of the 63 control samples 6 by both markers. Were positive (9.52%)showed very faint bands. Statistically, using EBER marker, association between EBV and breast cancer (p-0.0031) was observed compared to the control group but the association employing LMP1 marker was not significant (p-0.1563), Fisher’s exact test
  2. *P value < 0.05 is considered as significant (Fisher’s exact test). Abbreviation: EBER Epstein-Barr virus encoded RNA, LMP1 Latent membrane protein 1
Back to article page

Infectious Agents and Cancer

ISSN: 1750-9378

Contact us