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Table 2 HPV, p53 and p16 status versus patients’ characteristics

From: HPV infection and p53 and p16 expression in esophageal cancer: are they prognostic factors?

Treatment

HPVa

p

p16a

p

p53a

p

Negative

Positive

Negative

Positive

Negative

Positive

Sex

 Female

16 (21.3)

3 (25.0)

0.720

18 (16.7)

5 (38.5)

0.071

6 (16.2)

17 (21.0)

0.624

 Male

59 (78.7)

9 (75.0)

 

90 (83.3)

8 (61.5)

 

31 (83.8)

64 (79.0)

 

Age at diagnosis

  ≤ 60 years old

39 (52.0)

7 (58.3)

0.763

51 (47.2)

7 (53.8)

0.772

14 (37.8)

44 (54.3)

0.115

  > 60 years old

36 (48.0)

5 (41.7)

 

57 (52.8)

6 (46.2)

 

23 (62.2)

37 (45.7)

 

Alcohol consumption

  ≤ 20 years

19 (25.3)

2 (16.7)

0.722

21 (19.4)

3 (23.1)

0.720

7 (18.9)

17 (21.0)

0.813

  > 20 years

56 (74.7)

10 (83.3)

 

87 (80.6)

10 (76.9)

 

30 (81.1)

64 (79.0)

 

Tobacco consumption

  ≤ 20 years

14 (18.7)

5 (41.7)

0.125

25 (23.1)

1 (7.7)

0.295

8 (21.6)

18 (22.2)

0.572

  > 20 years

61 (81.3)

7 (58.3)

 

83 (76.9)

12 (92.3)

 

29 (78.4)

63 (77.8)

 

Clinical stage

 I or II

21 (29.2)

2 (16.7)

0.497

26 (26.0)

3 (23.1)

1.000

5 (14.3)

23 (30.3)

0.099

 III or IV

51 (70.8)

10 (83.3)

 

74 (74.0)

10 (76.9)

 

30 (85.7)

53 (69.7)

 

Histological grade

 Well differentiated

11 (15.1)

0 (0.0)

0.442

13 (12.3)

1 (7.7)

0.912

7 (18.9)

7 (8.9)

0.264

 Moderately differentiated

42 (57.5)

9 (75.0)

 

62 (58.5)

9 (69.2)

 

19 (51.4)

49 (62.0)

 

 Poorly differentiated

20 (27.4)

3 (25.0)

 

31 (29.2)

3 (23.1)

 

11 (29.7)

23 (29.1)

 

Surgery

 No

58 (77.3)

12 (100.0)

0.112

95 (88.0)

7 (53.8)

0.006

31 (83.8)

69 (85.2)

1.000

 Yes

17 (22.7)

0 (0.0)

 

13 (12.0)

6 (46.2)

 

6 (16.2)

12 (14.8)

 

Chemoradiotherapy

 No

18 (24.0)

0 (0.0)

0.140

24 (22.2)

2 (15.4)

0.803

7 (18.9)

17 (21.0)

0.871

 Chemo or Radio

25 (33.3)

6 (50.0)

 

38 (35.2)

4 (30.8)

 

12 (32.4)

29 (35.8)

 

 Chemo and Radio

32 (42.7)

6 (50.0)

 

46 (42.6)

7 (53.8)

 

18 (48.6)

35 (43.2)

 

HPV

 Negative

65 (85.5)

9 (90.0)

1.000

24 (88.9)

47 (83.9)

0.743

 Positive

 

11 (14.5)

1 (10.0)

 

3 (11.1)

9 (16.1)

 

p16a

 Negative

65 (87.8)

11 (91.7)

1.000

34 (91.9)

72 (88.9)

0.751

 Positive

9 (12.2)

1 (8.3)

 

 

3 (8.1)

9 (11.1)

 

p53a

 Negative

24 (33.8)

3 (25.0)

0.743

34 (91.9)

72 (88.9)

0.751

 Positive

47 (66.2)

9 (75.0)

 

3 (8.1)

9 (11.1)

 

 
  1. aThere are missing values
  2. Entries in boldface are significantly different