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Table 2 Presence of high risk HPV L1 and E7 viral genes and HPV E7 protein in benign prostate and prostate cancer (same sets of patients)

From: High risk human papilloma viruses (HPVs) are present in benign prostate tissues before development of HPV associated prostate cancer

  Benign prostate with subsequent prostate cancer Prostate cancer Difference in proportions between benign prostate and prostate cancer
HPV L1 gene 13/28
(46%)
8/28
(29%)
× 2 = 1.231
df = 1
p = 0.267 (ns)
HPV E7 gene 23/28
(82%)
19/28
(70%)
× 2 = 0.750
df = 1
p = 0.387 (ns)
HPV E7 protein 23/28
(82%)
8/28
(29%)
× 2 = 11.529
df = 1
p = <0.001 (sig)
  1. There were no statistically significant differences in the prevalence of HPV L1 and HPV E7 genes (as assessed by PCR) between prior benign prostate and later prostate cancer in the same patients. The differences in HPV E7 oncoprotein expression (as assessed by immunohistochemistry) were highly significant with much higher expression in the benign as compared to the later prostate cancer in the same patient
  2. A two-tailed McNemar test was used to assess the statistical significances
  3. × 2 = chi-square, d.f = degree of freedom. Sig = significant, ns = not significant