Skip to main content

Table 2 Differentially expressed proteins of Helicobacter pylori related to autoimmune atrophic gastritis (AAG), duodenal ulcer (DU) or gastric cancer (GC)

From: Protein signature characterizing Helicobacter pylori strains of patients with autoimmune atrophic gastritis, duodenal ulcer and gastric cancer

ID(a) Fold (b) Spot nr. MW
Da/pI
Accession
number(c)
Protein name, gene name(d) H. pylori strain Score Sequence
Coverage
p-value MS
AAG 9.31 13 27557/9.68 gi|238057731 tRNA pseudouridine synthase A, truA H. pylori P12 32 26% 0.0024 MALDI-TOF
AAG 7.15 254 6644/10.96 gi|226703094 50S ribosomal protein L30, rpmD Leptothrix cholodnii 37 30% 0.0045 MALDI-TOF
AAG 4.75 168 22335/5.88 gi|2507172 Probable peroxiredoxin or 26 kDa antigen, trxB H. pylori 82 52% 0.00072 MALDI-TOF
DU 3.25 212 30558/6.6 O25984 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase, ispE H. pylori 32 11% 0.043 MALDI-TOF
DU 3.13 227 13411/6.1 B2UW13 10 kDa chaperonin or GroES protein, groS H. pylori Shi470 80 42% 3.71E10-3 MALDI-TOF
DU 2.92 77 41655/5.92 gi|15611604 2-oxoglutarate-acceptor oxidoreductase subunit, oorA H. pylori P12 216 31% 3.42E-03 LC-MS/MS
DU 2.92 273 42658/6.04 METK_HELPG S-adenosylmethionine synthase, metK H. pylori G27 112 31% 3.42E-03 LC-MS/MS
DU 2.75 149 28658/7.3 E1PY38 Putative heme iron utilization protein, HPSJM 01705 H. pylori SJM180 78 50% 6.27E10-3 MALDI-TOF
DU 2.67 204 16812/5.69 gi|560032 Neutrophil activating protein, napA H. pylori 416 43% 0.029 LC-MS/MS
AAG 2.65 33 61816/5.64 gi|57014163 Urease β subunit, ureB H. pylori J99 102 46% 0.014 MALDI-TOF
DU 2.49 85 38364/6.2 E1Q554 Aliphatic amidase, amiE H. pylori PeCan4 80 31% 0.020 MALDI-TOF
AAG 2.48 57 67136/4.99 gi|226738136 Chaperone protein dnaK or Heat shock 70 kDa protein, grpE H. pylori Shi470 32 8% 0.0075 MALDI-TOF
AAG 2.44 34 61846/5.64 gi|57014163 Urease β subunit, ureB H. pylori P12 75 37% 0.0024 MALDI-TOF
DU 2.36 267 58700/8.6 B5Z7N5 Catalase, katA H. pylori G27 43 24% 1.38E-03 MALDI-TOF
DU 2.36 268 58700/8.6 B5Z7N5 Catalase, katA H. pylori G27 79 34% 1.38E-03 MALDI-TOF
AAG 2.22 166 22335/5.88 gi|2507172 Probable peroxiredoxin or 26 kDa antigen, trxB H. pylori P12 97 48% 0.0013 MALDI-TOF
DU 2.21 258 22314/5.16 SCOB_HELPJ Succinyl-CoA:3-ketoacid coenzyme A transferase subunit B, scoB H. pylori 325 16% 8.92E10-3 LC-MS/MS
AAG 2.11 39 58706/8.70 gi|2493545 Catalase, katA H. pylori 106 30% 0.0033 MALDI-TOF
DU 2.08 190 18528/5.1 B6JKY5 3-dehydroquinate dehydratase, aroQ H. pylori 32 24% 4.37E-04 MALDI-TOF
DU 1.97 265 52416/6.48 gi|317181962 Aspartate ammonia-lyase, aspA H. pylori F57 345 29% 1.76E-05 LC-MS/MS
DU 1.9 266 55022/6.50 gi|317009453 Leucyl aminopeptidase, pepA H. pylori India7 283 25% 1.76E-08 LC-MS/MS
DU 1.9 249 14685/4.65 gi|122695106 Inorganic phyrophosphatase, ppa H. pylori 425 34% 4.22E10-3 LC-MS/MS
DU 1.8 168 22335/5.9 P21762 Probable peroxiredoxin, tsaA H. pylori 48 56% 0.02 MALDI-TOF
DU 1.75 271 47660/6.7 Q9ZN36 Isocitrate dehydrogenase, icd H. pylori J99 70 30% 1.76E-03 MALDI-TOF
DU 1.75 270 47660/6.7 Q9ZN36 Isocitrate dehydrogenase, icd H. pylori J99 49 8% 1.76E-05 MALDI-TOF
DU 1.69 253 12018/5.16 THIO HELPJ Thioredoxin, trxA H. pylori J99 1159 56% 1.24E10-3 LC-MS/MS
DU 1.64 176 22518/7.57 gi|298735719 Orotate phosphoribosyltransferase, pyrE H. pylori B8 130 13% 1.59E-03 LC-MS/MS
AAG 1.62 65 20180/5.84 gi|208432952 Peptidoglycan-associated lipoprotein, pal H. pylori G27 41 17% 0.027 MALDI-TOF
DU 1.6 244 17495/4.45 gi|108563525 Flavodoxin, fldA H. pylori HPAG1 1590 79% 4.85E-05 LC-MS/MS
DU 1.5 272 41575/5.98 gi|317012405 2-oxoglutarate-acceptor oxidoreductase subunit, oorA H. pylori Lithuania75 173 33% 7.33E–03 LC-MS/MS
AAG 1.47 77 74074/5.11 gi|12230111 Flagellar hook-associated protein 2, fliD H. pylori J99 39 10% 0.045 MALDI-TOF
AAG 1.42 111 67838/6.17 gi|1706274 Bifunctional enzyme cysN/cysC, cysN Mycobacterium tuberculosis 44 14% 0.073 MALDI-TOF
DU −1.57 233 11804/10.25 RL21 HELHP 50S ribosomal protein L21, rplU H. hepaticus ATCC 51449 61 9% 0.026 LC-MS/MS
DU −1.65 95 38570/5.0 Q9ZJT5 DNA-directed RNA polymerase subunit alpha, rpoA H. pylori J99 35 18% 3.26E-05 MALDI-TOF
AAG −1.68 63 43734/5.17 gi|2494256 Elongation factor Tu, tuf H. pylori 79 33% 9.00E-05 MALDI-TOF
DU −1.7 262 25909/5.27 gi|15611222 Transcriptional regulator, jhp 0381 H. pylori J99 312 36% 0.049 LC-MS/MS
DU −1.73 234 10402/9.37 DBH HELPJ DNA-binding protein HU, hup HP 0835 H. pylori J99 52 11% 0.040 LC-MS/MS
DU −1.79 231 13411/6.12 CH10 HELPS 10 kDa chaperonin, groS H. pylori Shi470 53 25% 8.96E10–3 LC-MS/MS
DU −2.1 232 49972/6.6 Q1CTD7 Ribosomal protein S12 methylthiotransferase, rimO H. pylori HPAG1 32 13% 2.43E–03 MALDI-TOF
DU −2.39 141 63933/8.9 E1Q0U8 DNA primase, dnaG H. pylori SJM180 45 17% 9.87E–05 MALDI-TOF
DU –2.4 89 43734/5.2 P56003 Elongation factor Tu, tuf H. pylori 87 51% 8.57E–06 MALDI-TOF
AAG −2.43 40 55280/5.29 gi|226739893 ATP synthase subunit alpha or F-ATPase subunit alpha, atpA H. pylori 140 32% 0.0034 MALDI-TOF
AAG −2.44 42 53252/6.04 gi|60392282 Flagellin A, flhA H. pylori J99 88 30% 0.0098 MALDI-TOF
AAG −2.48 141 63933/8.9 E1Q0U8 DNA primase, dnaG H. pylori SJM180 45 17% 0.0089 MALDI-TOF
AAG −2.9 89 43734/5.17 gi|2494256 Elongation factor Tu, tuf H. pylori 90 33% 0.00013 MALDI-TOF
AAG −5.35 248 22335/5.88 gi|2507172 Probable peroxiredoxin or 26 kDa antigen, trxB H. pylori 44 34% 0.00095 MALDI-TOF
AAG −6.58 35 58321/5.44 gi|226704136 60 kDa chaperonin, GroL H. pylori P12 68 23% 0.0011 MALDI-TOF
  1. (a)DU: differential spots of H. pylori isolated from DU versus GC (fold values >1.5 or <1.5 indicate increase or decrease in content, respectively, in DU-H. pylori); AAG: differential spots of H. pylori isolated from AAG versus GC (fold values >1.5 or <1.5 indicate increase or decrease in content, respectively, in AAG-H. pylori); (b)fold difference calculated as log standardized abundance fold change; (c)accession number of NCNInr or SwissProt databases;(d)gene names released by HUGO Gene Nomenclature Committee, or gene names adopted by STRING when different from HUGO ones