Fig. 1From: Review on the role of the human Polyomavirus JC in the development of tumorsMolecular mechanisms of T-Ag induced- cell transformation. T-Ag binds to pRB family proteins, to βcatenin, p53 and IRS-1, inducing the expression of many genes involved in the advancement of the cell cycle and/or interfering with the apoptosis and the NHEJ double stranded DNA repair mechanism processes. Additionally, T-Ag promotes the induction of genetic instabilityBack to article page