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Table 2 Hazard ratios (HR) with 95 % confidence intervals (CI) for hepatocellular carcinoma (HCC) among 4270a study subjects, according to HCV RNA-positivity and FIB-4 index. Naples, 2003–2012

From: Infection with hepatitis viruses, FIB-4 index and risk of hepatocellular carcinoma in southern Italy: a population-based cohort study

HCV RNA

FIB-4 <1.45

FIB-4 1.45–3.25

FIB-4 >3.25

Subjects

No.

HCC cases

No. (%)

HRb (95 % CI)

Subjects

No.

HCC cases

No. (%)

HRb (95 % CI)

Subjects

No.

HCC cases

No. (%)

HRb (95 % CI)

Negative

3380

1 (0.03)

1*

604

0 (0.0)

0 (0-∞)

47

1 (2.1)

79.5 (4.9–1285)

Positive

61

0 (0.0)

0 (0-∞)

110

3 (2.7)

99.5 (10.3–957.3)

68

12 (17.6)

771.2 (100.0–5949)

  1. a99 HBsAg-positive and 89 anti-HCV-positive, HCV-RNA-negative study subjects were excluded. Information on FIB-4 index was not available for 34 remaining study subjects
  2. bHazard ratios adjusted for gender
  3. *Reference category