Molecular analysis of human Papillomavirus detected among women positive for cervical lesions by visual inspection with acetic acid/Lugol’s iodine (VIA/VILI) in Libreville, Gabon

Table 3 Nucleotide sequence variation in the E6 and LCR regions in HPV16 isolates

	E6 nucleotide position													LCR nucleotide position
Nucleotide position	109	132	143	145	196	255	256	286	289	295	335	350	403	7386	7393	7417	7435	7484	7489	7520	7668	7688	7713	7763	7785	7787	7825	7833	Variant	Class	Cytology
Predicted amino acid substitution	2 F	R10I/R10T	Q14D		V31	C51F		A61	V62	D64E	H78Y	L83V	L100
K02718	T	G	C	G	G	G	C	T	A	T	C	T	A	G	C	T	G	A	G	G	C	C	T	C	C	A	G	G
CHUA130001	-	-	-	-		-	-	-	-	-	-	G																	E	G350	LSIL
CHUA130002														-	-	-	A	C	A	A	T	A	-	T	T	-	A	T	Af 2	-	ASC-US
CHUA 130003														-	-	-	A	C	A	A	T	A	-	T	T	-	A	T	Af 2	-	HSIL
CHUA 130012	-	-	-	-		-	-	-	-	-	-	G																	E	G350	carcinoma
CHUA 130026	-	C	G	T	-	-	-	a	g	-	T	-																	Af 1	1a	Normal
CHUA 130035	-	C	G	T	-	-	-	a	g	-	T	-	-	-	-	-	-	-	A	A	-	A	A	T	T	-	-	T	Af 1	1a	HSIL
CHUA 130021	c	T	G	T		-	-	a	g	-	T	-	g																Af 2	a	carcinoma
CHUA 130024	c	T	G	T	-	-	-	a	g	-	T	-	g																Af 2	a	ASC-US
CHUA 140002	c	T	G	T	-	-	-	a	g	-	T	-	g	C	-	-	-	C	A	A	T	A	-	T	T	-	A	T	Af 2	a	carcinoma
CHUA140010	c	T	G	T	-	-	-	a	g		T	-	g	C	-	-	A	C	A	A	T	A	-	T	T	-	A	T	Af 2	-	Normal
CHUL140009	c	T	G	T	-	-	-	a	g		T	-	g																Af 2	a	HSIL
CHUL140002	c	T	G	T	-	-	-	a	g		T	-	g	C	-	-	A	C	A	A	T	A	-	T	T	-	A	T	Af 2	a	HSIL
CHUL140016														-	T	-	-	-	A	A	-	A	A	T	T	-	-	T	Af 1	-	carcinoma
CHUA 130025	-	-	G	T	a	T	T	a	g	G	T	-	-	-	-	C	-	-	A	A	T	A	-	T	T	T	-	T	Af 1	-	carcinoma

ISSN: 1750-9378