High-risk HPV is not associated with epithelial ovarian cancer in a Caucasian population

Table 2 Studies published during the last 20 years, reporting on HPV prevalence in EOC tissue

Author and publication year	Country of origin	Tissue type	Detection method	HPV genotypes	Number of cases of EOC	Number of HPV positive cases	HPV prevalence (%)
Asia					247	81	32.8
Shanmughapriya et al. 2012 [14]	India	Fresh	PCR	6	24	6	25
Atalay et al. 2007 [30]	Turkey	FFPE	PCR	16,33	94	8	8.5
Kuscu et al. 2005 [57]	Turkey	FFPE	In situ hybridization	Not specified	40	15	37.5
Wu et al. 2003 [13]	China	FFPE	In situ hybridization	16,18	50	26	52
Li et al. 2002 [33]	China	FFPE	PCR	Not specified	39	26	66.7
Europe, Western					274	1	0.4
Idahl et al. 2010 [18]	Sweden	Fresh frozen	PCR		52	0	0
Giordano et al. 2008 [12]	Italy	FFPE	PCR	Not specified	50	1	2
Wentzensen et al. 2008 [29]	Germany	FFPR	PCR		74	0	0
Anttila et al. 1999 [15]	Finland	FFPE	PCR		98	0	0
Europe, Eastern					71	16	22.5
Bilyk et al. 2011 [28]	Ukraine	FFPE	PCR	16,18	53	9	17
Zimna et al. 1997 [35]	Poland	Fresh frozen	PCR	18	18	7	38.9
Middle East					100	42	42
Al-Shabanah et al. 2013 [11]	Saudi Arabia	FFPE	PCR	16,18,45	100	42	42
USA					36	0	0
Quirk et al. 2006 [16]	USA	Fresh frozen	PCR		16	0	0
Chen et al. 1999 [34]	USA	FFPE	PCR		20	0	0

Abbreviations: EOC epithelial ovarian cancer, PCR polymerase chain reaction, HPV human papillomavirus, FFPE formalin-fixed paraffin-embedded

ISSN: 1750-9378