Table 1 Drugs used for screening in SPEL cells
Drug | Company, Catalog no. | Category | Concentration |
|---|---|---|---|
No drug | - | Control | - |
DMSO (Dimethyl sulfoxide) | Sigma-Aldrich, 34869 | Control | - |
Doxorubicin | Kyowa-Kirin, Adriacin | Anti-cancer drug | 10 μM |
Vincristine | Nippon-Kayaku, Oncovin | Anti-cancer drug | 10 μM |
Etoposide | Sigma-Aldrich, E1383 | Anti-cancer drug | 10 μM |
Anti-IgM SA-DA4 | Abcam, ab99740 | Anti-IgM | 10 μM |
Anti-IgM FC | Abcam, ab772 | Anti-IgM | 10 μM |
Anti-IgM UNLB | Southern Biotech, 2020-01 | Anti-IgM | 10 μM |
IC-261 | Sigma-Aldrich, I0658 | Casein kinase inhibitor | 10 μM |
TBB | Sigma-Aldrich, T0826 | Casein kinase inhibitor | 10 μM |
D4476 | Sigma-Aldrich, D1944 | Casein kinase inhibitor | 10 μM |
TPA (tetradecanylphorbol acetate) | Sigma-Aldrich, P8139 | Dicarboxylic acid | 20 ng/mL |
SBHA (suberic bishydroxamate) | R &D Systems, 38937-66-5 | HDAC inhibitor | 10 μM |
Trichostatin A | Sigma-Aldrich, T8552 | HDAC inhibitor | 10 μM |
Cl994 | Sigma-Aldrich, C0621 | HDAC inhibitor | 10 μM |
SAHA | Sigma-Aldrich, SML0061 | HDAC inhibitor | 10 μM |
Tubacin | Sigma-Aldrich, SML0065 | HDAC inhibitor | 10 μM |
Scriptaid | Sigma-Aldrich, S7817 | HDAC inhibitor | 10 μM |
Panobinostat | Sigma-Aldrich, EPI009 | HDAC inhibitor | 10 μM |
Sodium Butyrate | Sigma-Aldrich, B5887 | HDAC inhibitor | 1.25 μM |
SC514 | Santa Cruz, sc-205504 | IKKb inhibitor | 10 μM |
Thalidomide | Sigma-Aldrich, T144 | Immunomodulatory drug | 10 μM |
Pomalidomide | Sigma-Aldrich, P0018 | Immunomodulatory drug | 10 μM |
Lenalidomide | Santa Cruz, sc-218656 | Immunomodulatory drug | 10 μM |
Cyclophosphamide | Sigma-Aldrich, C7397 | Immunosuppressant | 10 μM |
AG490 (Tyrphostin AG 490) | Sigma-Aldrich, T3434 | JAK inhibitor | 10 μM |
SP600125 | Sigma-Aldrich, S5567 | JNK inhibitor | 10 μM |
Rapamycin | Sigma-Aldrich, R8781 | mTOR inhibitor | 10 μM |
BAY11-7082 | Sigma-Aldrich, B5556 | NF-kB inhibitor | 10 μM |
LY-294002 | Sigma-Aldrich, L9908 | PI3K inhibitor | 10 μM |
Z-leu-leu-leu-H | Peptide Institute, 3175-v | Proteasome inhibitor | 10 μM |
Bortezomib | Calbiochem, 5.04314.0001 | Proteasome inhibitor | 10 μM |
Simvastatin | MSD, Lipovas | Statin | 10 μM |
Lovastatin | Sigma-Aldrich, 1370600 | Statin | 10 μM |
Prednisolone | Shionogi, Predonine | Steroid | 10 μM |
Dexamethasone | Sigma-Aldrich, D4902 | Steroid | 10 μM |