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Table 2 p53 expression in relation to clinical parameters and HPV status in Kazakh patients with ESCC

From: p53 expression but not p16INK4A correlates with human papillomavirus-associated esophageal squamous cell carcinoma in Kazakh population

Clinical properties Total p53 expression (n/%)
Negative (%) Positive (%) P value
Gender
 Male 106 10(52.6 %) 96(66.7 %) 0.228
 Female 57 9(47.4 %) 48(33.3 %)
Age (mean)
  < 58 82 7(36.8 %) 75(53.6 %) 0.171
  ≥ 58 77 12(63.2 %) 65(46.4 %)
Histopathological gradea
 Well 40 8(42.1 %) 32(22.9 %) 0.070
 Moderate 98 8(42.1 %) 91(65.0 %)
 Poor 20 3(15.8 %) 17(12.1 %)
Invasion depth
 T1-T2 76 8(47.1 %) 68(51.1 %) 0.752
 T3-T4 74 9(52.9 %) 65(48.9 %)
Lymphatic invasion
 N0 68 6(33.3 %) 62(49.2 %) 0.207
 N1-N3 76 12(66.7 %) 64(50.8 %)
TNM Staging
 I/II 79 9(60.0 %) 70(64.2 %) 0.750
 III/IV 45 6(40.0 %) 39(35.8 %)
HPV infection
 Negative 67 4(28.6 %) 63(57.8 %) 0.039
 Positive 56 10(71.4 %) 46(42.2 %)
  1. P < 0.05 indicates a significant association among the variables
  2. a Well differentiation vs. moderate + poor differentiation
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Infectious Agents and Cancer

ISSN: 1750-9378

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