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Fig. 4 | Infectious Agents and Cancer

Fig. 4

From: The DC-SIGN-CD56 interaction inhibits the anti-dendritic cell cytotoxicity of CD56 expressing cells

Fig. 4

NK–mediated cytotoxicity of DC but not K562 depends on both DC-SIGN and CD56 trans-homophilic interaction. a The dotplots of isolated CD56pos cells (NK), DC-SIGN expressing DCs and their co-culture. Preincubation of DCs with anti-DC-SIGN antibodies or mannan did not change the picture; b The CD56pos cell cytotoxicity of K562, DC-SIGN-expressing K562, iDCs and mDCs taken in different effector/target ratios. c Pre-incubation of DCs with DC-SIGN lectin inhibiting antibodies (AZD1/D2) increases the CD56 cytotoxicity of DC. Error bars represent ± SD of experiment quadruplicates. d The trans-homophilic interaction blocking peptide C3d inhibits the CD56pos cell cytotoxicity of DCs. Error bars represent ± SD of experiment quadruplicates. In experiments c and d ratio DC:NK was 1:8. The results are representative from several experiments

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