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Fig. 2 | Infectious Agents and Cancer

Fig. 2

From: The DC-SIGN-CD56 interaction inhibits the anti-dendritic cell cytotoxicity of CD56 expressing cells

Fig. 2

DC-SIGN-Fc binds in a C-type lectin-specific manner to CD56pos cells expressing Lewis Y carbohydrates. a The dot plots of activated and freshly isolated PBLs stained for DC-SIGN-L, CD56 and CD16. b The dot plots of activated PBLs stained for CD56 and DC-SIGN-L. c The DC-SIGN-Fc binding to CD56pos cells was analyzed in the absence and in the presence of DC-SIGN inhibitors: mannan (2 mg/ml), EGTA (10 mM). Human serum (Hum. Serum) was used as a negative control for unspecific human Fc fragment bindings. The experiment was performed in triplicates and error bars represent ± SD of triplicates. d Histograms of CD56pos (clear plots) and CD56neg (grey plots) activated PBLs stained for -Lewis X (left) and Lewis Y (right) carbohydrates surface expression with specific antibodies

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