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Table 1 Age-stratified performance of HPV16/18 genotyping for the detection of high-grade cervical lesions among 776 hrHPV positive women, Chile 2010.

From: HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile

   

Sensitivity

Specificity

PPV

NPV

Lesion

Age

[n lesions]

% (95 % CI)

CIN2+

<30

[24]

62.5

54.7

16.1

91.3

   

(40.6–81.2)

(46.9–62.2)

(9.3–25.2)

(84.1–95.9)

 

≥30

[63]

54.0

66.3

16.4

92.2

   

(40.9–66.6)

(62.1–70.4)

(11.6–22.1)

(89.0–94.7)

 

All

[87]

56.3

63.4

16.3

92.0

   

(45.9–66.7)

(59.8–67.0)

(12.1–20.4)

(89.6–94.4)

CIN3+

<30

[11]

81.8

54.6

9.7

98.1

   

(48.2–97.7)

(47.1–61.9)

(4.5–17.6)

(93.2–99.8)

 

≥30

[39]

64.1

66.2

12.0

96.2

   

(47.2–78.8)

(62.0–70.1)

(7.9–17.2)

(93.7–97.9)

 

All

[50]

68.0

63.2

11.3

96.6

   

(55.1–80.9)

(59.7–66.7)

(7.7–14.9)

(95.0–98.3)

  1. CIN2+ cervical intraepithelial neoplasia grade 2 or worse; CIN3+ cervical intraepithelial neoplasia grade 3 or worse; PPV positive predictive value; NPV negative predictive value