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Table 1 Age-stratified performance of HPV16/18 genotyping for the detection of high-grade cervical lesions among 776 hrHPV positive women, Chile 2010.

From: HPV16/18 genotyping for the triage of HPV positive women in primary cervical cancer screening in Chile

    Sensitivity Specificity PPV NPV
Lesion Age [n lesions] % (95 % CI)
CIN2+ <30 [24] 62.5 54.7 16.1 91.3
    (40.6–81.2) (46.9–62.2) (9.3–25.2) (84.1–95.9)
  ≥30 [63] 54.0 66.3 16.4 92.2
    (40.9–66.6) (62.1–70.4) (11.6–22.1) (89.0–94.7)
  All [87] 56.3 63.4 16.3 92.0
    (45.9–66.7) (59.8–67.0) (12.1–20.4) (89.6–94.4)
CIN3+ <30 [11] 81.8 54.6 9.7 98.1
    (48.2–97.7) (47.1–61.9) (4.5–17.6) (93.2–99.8)
  ≥30 [39] 64.1 66.2 12.0 96.2
    (47.2–78.8) (62.0–70.1) (7.9–17.2) (93.7–97.9)
  All [50] 68.0 63.2 11.3 96.6
    (55.1–80.9) (59.7–66.7) (7.7–14.9) (95.0–98.3)
  1. CIN2+ cervical intraepithelial neoplasia grade 2 or worse; CIN3+ cervical intraepithelial neoplasia grade 3 or worse; PPV positive predictive value; NPV negative predictive value