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Table 2 Associations between Merkel cell polyomavirus and cutaneous squamous cell carcinoma by tumor MCV DNA status

From: Merkel cell polyomavirus (MCV) T-antigen seroreactivity, MCV DNA in eyebrow hairs, and squamous cell carcinoma

  Controls (N = 300) MCV tumor-negative SCC cases (N = 89) MCV tumor-positive SCC cases (N = 55) p-value
MCV biomarker n (%) n (%) OR (95 % CI)* n (%) OR (95 % CI)*  
Seropositivity to MCV T-Ag (>50 MFI)       
MCV small T-Ag 7 (2.3) 2 (2.2) 0.63 (0.12–3.32) 0 (0) Could not be estimated 0.862
MCV large T-Ag exon 1 3 (1.0) 1 (1.1) 1.11 (0.11–11.61) 0 (0) Could not be estimated 0.996
MCV large T-Ag exon 2 18 (6) 10 (11.2) 1.50 (0.63–3.53) 5 (9.1) 1.06 (0.35–3.2) 0.640
MCV large T-Ag 22 (7.3) 9 (10.1) 1.10 (0.47–2.6) 6 (10.9) 1.06 (0.38–2.93) 0.975
  Controls MCV-DNA negative SCC cases MCV-DNA positive SCC cases p-value
(n = 292) (n = 86) (n = 55)
   n (%) OR (95 % CI)* n (%) OR (95 % CI)*  
MCV DNA present in eyebrow hairs 109 (37.3) 26 (30.2) 0.58 (0.34–1.01) 42 (76.4) 4.05 (2.01–8.18) 1.06 × 10 −6
  1. MCV Merkel cell polyomavirus, SCC cutaneous squamous cell carcinoma. * Odds ratios (OR) and 95 % confidence intervals (CI) calculated separately SCC cases with or without MCV DNA in their tumors using polynomial logistic regression, adjusting for age and gender