From: Inconclusive role of human papillomavirus infection in breast cancer
Variable | No. of studies | Case vs Control | P for heterogeneity | |
---|---|---|---|---|
OR(95 % CI)a | OR(95%CI)b | |||
all | 16 | 3.20(2.28–4.51) | 3.24(1.59–6.57) | 0.000 |
Region | Â | Â | Â | |
Asia | 9 | 2.81(1.84–4.28) | 2.87(1.05–7.85) | 0.000 |
South America | 4 | 4.70(2.18–10.14) | 6.46(0.62–67.88) | 0.007 |
Europe and Oceania | 3 | 3.16(1.27–7.90) | … | 0.611 |
DNA source | Â | Â | Â | |
Fixed tissue | 12 | 2.31(1.55–3.45) | 2.23(0.99–5.00) | 0.004 |
Fresh tissue | 4 | 7.88(3.99–15.60) | … | 0.458 |
PCR primers | Â | Â | Â | |
Broad-spectrum primers | 10 | 5.66(3.40–9.45) | … | 0.566 |
Type-specific primers | 4 | 3.34(1.72–6.47) | 3.12(0.29–33.52) | 0.002 |
Combined primers | 2 | 0.68(0.32–1.45) | … | 0.614 |
Publication period | Â | Â | Â | |
1992–2006 | 6 | 4.12(2.42–7.02) | … | 0.111 |
2007–2012 | 10 | 2.69(1.73–4.20) | 3.10(1.07–8.96) | 0.000 |