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Table 5 Associations Between HPV prevalence and breast cancer Grouped by Selected Factors

From: Inconclusive role of human papillomavirus infection in breast cancer

Variable

No. of studies

Case vs Control

P for heterogeneity

OR(95 % CI)a

OR(95%CI)b

all

16

3.20(2.28–4.51)

3.24(1.59–6.57)

0.000

Region

   

Asia

9

2.81(1.84–4.28)

2.87(1.05–7.85)

0.000

South America

4

4.70(2.18–10.14)

6.46(0.62–67.88)

0.007

Europe and Oceania

3

3.16(1.27–7.90)

…

0.611

DNA source

   

Fixed tissue

12

2.31(1.55–3.45)

2.23(0.99–5.00)

0.004

Fresh tissue

4

7.88(3.99–15.60)

…

0.458

PCR primers

   

Broad-spectrum primers

10

5.66(3.40–9.45)

…

0.566

Type-specific primers

4

3.34(1.72–6.47)

3.12(0.29–33.52)

0.002

Combined primers

2

0.68(0.32–1.45)

…

0.614

Publication period

   

1992–2006

6

4.12(2.42–7.02)

…

0.111

2007–2012

10

2.69(1.73–4.20)

3.10(1.07–8.96)

0.000

  1. CI confidence ratio, OR odds ratio
  2. aFixed effects model
  3. bRandom effects model