Fig. 1
Representative immunohistochemistry results of pRb, p53, and p16INK4a. a: pRb immunohistochemistry of SCC without HPV infection. Bar = 100 μm. b: p53 immunohistochemistry of SCC part of inverted papilloma with SCC. The case showed HPV-16 positive. Bar = 100 μm. c: p16INK4a expression in SCC with HPV-18 positivity. Tumor cells showed strong immunoreaction to p16INK4a in this case. Bar = 100 μm. d: pRb expression in chronic rhinosinusitis. This case was HPV negative. Epithelial cells showed diffuse pRb immunoreaction. Bar = 100 μm. e: p53 expression in chronic rhinosinusitis. This case was also HPV negative. Epithelial cells showed no p53 immunoreaction. Bar = 100 μm. f: p16INK4a expression in chronic rhinosinusitis. This case was HPV negative. The epithelial cells showed no p16INK4a immunoreaction. Bar = 100 μm