Table 1 Nucleotide sequence variations of HPV-16 E6 and E7 genes, predicted amino-acid changes ant lineage classification in Southwest Congolese women

1

1

1

1

1

1

1

1

1

1

2

2

2

2

2

3

4

6

6

7

7

0

3

3

3

3

4

4

4

4

8

5

8

8

8

9

3

0

2

4

8

9

9

1

2

7

8

1

2

3

5

8

5

5

6

9

5

5

3

2

7

9

5

HPV16 Ref (NC_001526)

T

A

G

T

T

C

A

C

G

G

G

C

T

A

T

C

A

G

A

T

T

Variant Lineages

Variant Sub-lineages

Novel nomenclature

Prevalence

No. (%)

Af-1

Af-la

B1

4 (30.7)

C

g

G

T

C

a

g

T

c

g

Af-Ib/G295

B2

1 (7.7)

C

G

T

a

g

G

T

c

g

Af-Ib/G131

B2

2 (15.4)

G

C

G

T

a

g

T

c

g

Af-2

Af-2a/r

C/C1

3 (23.0)

c

T

G

T

a

g

T

g

A*

c

g

Af-2a/C109/C138

1 (7.7)

c

T

C

G

T

a

g

G

T

g

G

c

g

Af-2a/C109/A137

1 (7.7)

c

T

A

G

G

T

a

g

T

g

G

c

g

Af-2a/C109/G285

1 (7.7)

c

T

G

T

G

a

g

T

g

G

c

g

Mutation prevalence (%)

46.1

15.4

53.8/46.1

7.7

7.7

7.7

7.7

100

100

30.7

15.4

7.7

100

100

7.7

100

46.1

23.0

23.0

100

100