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Table 1 Nucleotide sequence variations of HPV-16 E6 and E7 genes, predicted amino-acid changes ant lineage classification in Southwest Congolese women

From: Genetic variability in E6 and E7 oncogenes of human papillomavirus Type 16 from Congolese cervical cancer isolates

     E6 nucleotide position   E7 nucleotide position
    Amino acid changes   R10G R101/R10T L12I L12S P13G   Q14D Q14H E29Q C51F A6IG    D64E H78Y   D2IN N29S   
     1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 3 4 6 6 7 7
     0 3 3 3 3 4 4 4 4 8 5 8 8 8 9 3 0 2 4 8 9
     9 1 2 7 8 1 2 3 5 8 5 5 6 9 5 5 3 2 7 9 5
    HPV16 Ref (NC_001526) T A G T T C A C G G G C T A T C A G A T T
Variant Lineages Variant Sub-lineages Novel nomenclature Prevalence                      
No. (%)
Af-1 Af-la B1 4 (30.7)    C      g G T C   a g   T     c g
Af-Ib/G295 B2 1 (7.7)    C       G T    a g G T     c g
Af-Ib/G131 B2 2 (15.4)   G C       G T    a g   T     c g
Af-2 Af-2a/r C/C1 3 (23.0) c   T      G T     a g   T g A*   c g
Af-2a/C109/C138 1 (7.7) c   T   C    G T     a g G T g   G c g
Af-2a/C109/A137 1 (7.7) c   T A   G   G T     a g   T g   G c g
Af-2a/C109/G285 1 (7.7) c   T      G T    G a g   T g   G c g
    Mutation prevalence (%) 46.1 15.4 53.8/46.1 7.7 7.7 7.7 7.7 100 100 30.7 15.4 7.7 100 100 7.7 100 46.1 23.0 23.0 100 100
  1. Capital letters indicate variants with an amino acid change, Lower-case letters indicate silent mutations, M, missense; S, silence; The asterisk (*) indicates mutations never described.