HPV prevalence and risk of pre-cancer and cancer in regular immigrants in Italy: results from HPV DNA test-based screening pilot programs

Table 2 Main data and principal performance indicators of seven Italian pilot programmes adopting HPV as primary screening test followed by cytology triage, by country of birth

					Relative risk immigrants vs. Italians
	Italy-born		Born abroad		Crude RR	95% CI	Age adjusted RR	95% CI
	N	(%)*	N	(%)*
Invited Population (N)	140,015		22,814
Undelivered letters	1,305	0.9	1196	5.2
Participants	73,023	52.2	9941	43.6	0.84	(0.82-0.85)
Participation excluding undelivered letters (%)		52.6		46.0	0.87	(0.86-0.89)
HPV tests performed	72,176		9680
HPV positive	4,421	6.1	751	7.8	1.27	(1.18-1.36)	1.18	(1.13-1.22)
cytological triage*
Negative	1,925	48.4	326	49.2
Inadequate	180	4.5	24	3.6
ASC-US	444	11.2	66	10.0
AGC	17	0.4	5	0.8
L-SIL	1,173	29.5	174	26.3
ASC-H	74	1.9	22	3.3
H-SIL	158	4.0	42	6.3
Cancer	3	0.1	3	0.5
Total ASC-US+ (% of HPV positive)	1,869	47.0	312	47.1	0.98	(0.87-1.07)	0.95	(0.90-0.99)
Referred to colposcopy	1,968	2.7	324	3.3	1.23	(1.09-1.38)	1.22	(1.09-1.37)
Compliance to colposcopy	1,840	93.5	297	91.7	0.98	(0.95-1.02)
Detection rate for CIN3+ (‰ screened women)	163	2.3	50	5.2	2.29	(1.67-3.14)	2.29	(1.90-2.75)
Detection rate for CIN2+ (‰ screened women)	342	4.7	79	8.2	1.72	(1.35-2.20)	1.65	(1.45-1.89)
CIN2	179	52.3	29	36.7
CIN3 + adeno in situ	153	44.7	45	56.7
Invasive Cancer	10	5.6	5	17.2	3.73	(1.27-10.90)	3.9	(1.33-11.41)
Positive predictive value of colposcopy referral		18.6		26.6	1.43	(1.16-1.77)	1.38	(1.12-1.71)

*cytology triage results were missing for 447 and 89 women born in Italy and abroad, respectively.

ISSN: 1750-9378