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Table 2 Main data and principal performance indicators of seven Italian pilot programmes adopting HPV as primary screening test followed by cytology triage, by country of birth

From: HPV prevalence and risk of pre-cancer and cancer in regular immigrants in Italy: results from HPV DNA test-based screening pilot programs

      Relative risk immigrants vs. Italians
  Italy-born Born abroad Crude RR 95% CI Age adjusted RR 95% CI
  N (%)* N (%)*     
Invited Population (N) 140,015   22,814      
Undelivered letters 1,305 0.9 1196 5.2     
Participants 73,023 52.2 9941 43.6 0.84 (0.82-0.85)   
Participation excluding undelivered letters (%)   52.6   46.0 0.87 (0.86-0.89)   
HPV tests performed 72,176   9680      
HPV positive 4,421 6.1 751 7.8 1.27 (1.18-1.36) 1.18 (1.13-1.22)
cytological triage*         
   Negative 1,925 48.4 326 49.2     
   Inadequate 180 4.5 24 3.6     
   ASC-US 444 11.2 66 10.0     
   AGC 17 0.4 5 0.8     
   L-SIL 1,173 29.5 174 26.3     
   ASC-H 74 1.9 22 3.3     
   H-SIL 158 4.0 42 6.3     
   Cancer 3 0.1 3 0.5     
Total ASC-US+ (% of HPV positive) 1,869 47.0 312 47.1 0.98 (0.87-1.07) 0.95 (0.90-0.99)
Referred to colposcopy 1,968 2.7 324 3.3 1.23 (1.09-1.38) 1.22 (1.09-1.37)
Compliance to colposcopy 1,840 93.5 297 91.7 0.98 (0.95-1.02)   
Detection rate for CIN3+ (‰ screened women) 163 2.3 50 5.2 2.29 (1.67-3.14) 2.29 (1.90-2.75)
Detection rate for CIN2+ (‰ screened women) 342 4.7 79 8.2 1.72 (1.35-2.20) 1.65 (1.45-1.89)
   CIN2 179 52.3 29 36.7     
   CIN3 + adeno in situ 153 44.7 45 56.7     
   Invasive Cancer 10 5.6 5 17.2 3.73 (1.27-10.90) 3.9 (1.33-11.41)
Positive predictive value of colposcopy referral   18.6   26.6 1.43 (1.16-1.77) 1.38 (1.12-1.71)
  1. *cytology triage results were missing for 447 and 89 women born in Italy and abroad, respectively.