Figure 1From: Epstein-Barr virus and telomerase: from cell immortalization to therapyTERT inhibition induces EBV lytic cycle. In EBV-infected B cells, TERT up-regulates the expression of BATF, a negative regulator of BZLF1, thus preserving EBV latency. Following TERT inhibition, BATF level significantly decreases; the expression of BZLF1 leads to the induction of lytic proteins and a complete EBV lytic cycle.Back to article page