a1 (X20) and a2 (X40). Staining for P16INK4A in majority of the neoplastic cells showed intense nuclear staining, which reflects the functional role of p16 in control of cell cycle prior to the S-phase. In some cells, cytoplasmic positivity appeared prominent. b1 (X20) and b2 (X40). EGFR staining was observed to be brown membrane and cytoplasmic, uniformly distributed in all the squamous epithelial cells. c1 (X10) and c2 (X20). Staining for pEGFR showed complete brown membrane and cytoplasmic reaction in all epithelial tumors cells.