Figure 3

Immunoistochemical staining for p24 and Tat in HIV⁺vs. HIV^-tumors. (a) IHC using an anti-p24 antibody showed marked positivity of macrophages in a B-cell lymphoma of a HIV-positive subject. (b-c) IHC using an anti-Tat antibody in HIV-negative (b) and HIV-positive cases (c). Marked positivity to Tat of uninfected B-cells is visible in HIV-positive tumors, thus indicating that a soluble form of the protein is released from infected cells and enters neighbouring uninfected ones.