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Figure 3 | Infectious Agents and Cancer

Figure 3

From: The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets

Figure 3

Intracellular pathway associated with IGF1R activation. IGF1R activation by INS, IGF1 and IGF2, leads to autophosphorylation on tyrosines 1131, 1135 and 1136 in the kinase domain, followed by recruitment of specific docking intermediates, such as members of the IRS family (IRS-1, IRS-2, IRS-3, IRS-4). This molecule link the IGF1R to diverse signalling pathways, allowing the induction of growth, transformation, differentiation and protection against apoptosis, primarily through the activation of the PI3K/Akt/mTOR and the Ras GTPase/Raf-1 (Raf)/Mek (MAPK)/Erk (ERK1/2) signalling pathways.

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