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Table 3 MDM2 (rs2278744) polymorphisms in patients with HPV and cervical lesions of low degree (LSIL) and high degree (HSIL) and healthy patients with contraceptive as co-factor

From: MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives

  Cases Normal cytology p-value; OR [95% C.I.]
  Total SILa LSILb HSILc Controld Total SIL vs. C LSIL vs. C HSIL vs. C HSIL vs. LSIL
SNP309 rs2278744         
Alelles         
T 254 (0.61) 165 (0.63) 89 (0.59) 92 (0.64) Reference Reference Reference Reference
G 158 (0.39) 95 (0.37) 63 (0.41) 52 (0.36) 0.81; 1.05 [0.71-1.54] 0.98; 0.99 [0.66-1.51] 0.68; 1.12 [0.70-1.75] 0.56; 1.15 [0.74-1.75]
Genotypes         
TT 74 (0.36) 54 (0.41) 20 (0.26) 30 (0.42) Reference Reference Reference Reference
TG 106 (0.51) 57 (0.44) 49 (0.64) 32 (0.44) 0.59; 0.74 [0.42-1.33] 0.99; 1.2 [0.55-1.91] 10.06; 2.24 [1.08-4.63] 20.02; 2.31 [1.21-4.41]
GG 26 (0.13) 19 (0.15) 7 (0.10) 10 (0.14) 0.59; 0.95 [0.41-2.21] 0.99; 0.98 [0.40-2.39] 0.06; 1.06 [0.34-3.25] 0.02; 1.07 [0.39-2.96]
  1. p-value adjusted with contraceptive.
  2. p < 0.05 – statistically significant.
  3. aSIL: Squamous intraepithelial lesions.
  4. bLSIL: Low-grade squamous intraepithelial lesions.
  5. cHSIL: High-grade squamous intraepithelial lesions.
  6. dC: Control - Normal cytology.
  7. 1In overdominant model the p-value was 0.019; OR = 2.21 (95% CI, 1.13-4.30).
  8. 2In dominant model the p-value was 0.02; OR = 2.01 (95% CI, 1.07-3.76) and in overdominant model, the p-value was 0.006; OR = 2.27 (95% CI, 1.25-4.10).