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Table 3 MDM2 (rs2278744) polymorphisms in patients with HPV and cervical lesions of low degree (LSIL) and high degree (HSIL) and healthy patients with contraceptive as co-factor

From: MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives

 

Cases

Normal cytology

p-value; OR [95% C.I.]

 

Total SILa

LSILb

HSILc

Controld

Total SIL vs. C

LSIL vs. C

HSIL vs. C

HSIL vs. LSIL

SNP309 rs2278744

        

Alelles

        

T

254 (0.61)

165 (0.63)

89 (0.59)

92 (0.64)

Reference

Reference

Reference

Reference

G

158 (0.39)

95 (0.37)

63 (0.41)

52 (0.36)

0.81; 1.05 [0.71-1.54]

0.98; 0.99 [0.66-1.51]

0.68; 1.12 [0.70-1.75]

0.56; 1.15 [0.74-1.75]

Genotypes

        

TT

74 (0.36)

54 (0.41)

20 (0.26)

30 (0.42)

Reference

Reference

Reference

Reference

TG

106 (0.51)

57 (0.44)

49 (0.64)

32 (0.44)

0.59; 0.74 [0.42-1.33]

0.99; 1.2 [0.55-1.91]

10.06; 2.24 [1.08-4.63]

20.02; 2.31 [1.21-4.41]

GG

26 (0.13)

19 (0.15)

7 (0.10)

10 (0.14)

0.59; 0.95 [0.41-2.21]

0.99; 0.98 [0.40-2.39]

0.06; 1.06 [0.34-3.25]

0.02; 1.07 [0.39-2.96]

  1. p-value adjusted with contraceptive.
  2. p < 0.05 – statistically significant.
  3. aSIL: Squamous intraepithelial lesions.
  4. bLSIL: Low-grade squamous intraepithelial lesions.
  5. cHSIL: High-grade squamous intraepithelial lesions.
  6. dC: Control - Normal cytology.
  7. 1In overdominant model the p-value was 0.019; OR = 2.21 (95% CI, 1.13-4.30).
  8. 2In dominant model the p-value was 0.02; OR = 2.01 (95% CI, 1.07-3.76) and in overdominant model, the p-value was 0.006; OR = 2.27 (95% CI, 1.25-4.10).
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Infectious Agents and Cancer

ISSN: 1750-9378

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