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Table 4 Microbiologically documented infection observed during acute myeloid leukemia therapy in children with Down syndrome

From: Infections in children with down syndrome and acute myeloid leukemia: a report from the Canadian infections in AML research group

 

DS-specific AML protocol (N = 12)

Non-DS specific AML protocol (N = 38)

Sterile site bacteria*

  

Gram positive

  

  Viridans group streptococci

5

4

  Coagulase negative staphylococci

0

3

  Enterococcus faecalis

0

2

  Othera

0

1

Gram negative

  

  Escherichia coli

1

3

  Klebsiella pneumoniae

0

1

  Enterobacter cloacae

0

2

  Othersb

1

2

Fungus*

  

  Candida species

0

2

Virus*

  

  Herpes simplex virus

1

1

  Respiratory syncytial virus

1

3

  Torovirus

1

4

  Othersc

1

5

Clostridium difficile*

1

5

  1. Abbreviations: AML acute myeloid leukemia, DS Down syndrome.
  2. *For bacterial infections other than C. difficile, only sterile site positive cultures are shown. For fungi, viruses and C. difficile, both sterile and non-sterile site positive cultures are shown.
  3. aOther: beta-hemolytic Streptococcus (n = 1).
  4. bOthers: Citrobacter freundii (n = 1) for Down syndrome protocol group; Enterobacter species (n = 1) and Haemophilus influenza (n = 1) for non-Down syndrome protocol group.
  5. cOther: parvovirus (n = 1) for Down syndrome protocol group; parainfluenza (n = 3) and rotavirus (n = 2) for non-Down syndrome protocol group.