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Table 4 Microbiologically documented infection observed during acute myeloid leukemia therapy in children with Down syndrome

From: Infections in children with down syndrome and acute myeloid leukemia: a report from the Canadian infections in AML research group

  DS-specific AML protocol (N = 12) Non-DS specific AML protocol (N = 38)
Sterile site bacteria*   
Gram positive   
  Viridans group streptococci 5 4
  Coagulase negative staphylococci 0 3
  Enterococcus faecalis 0 2
  Othera 0 1
Gram negative   
  Escherichia coli 1 3
  Klebsiella pneumoniae 0 1
  Enterobacter cloacae 0 2
  Othersb 1 2
Fungus*   
  Candida species 0 2
Virus*   
  Herpes simplex virus 1 1
  Respiratory syncytial virus 1 3
  Torovirus 1 4
  Othersc 1 5
Clostridium difficile* 1 5
  1. Abbreviations: AML acute myeloid leukemia, DS Down syndrome.
  2. *For bacterial infections other than C. difficile, only sterile site positive cultures are shown. For fungi, viruses and C. difficile, both sterile and non-sterile site positive cultures are shown.
  3. aOther: beta-hemolytic Streptococcus (n = 1).
  4. bOthers: Citrobacter freundii (n = 1) for Down syndrome protocol group; Enterobacter species (n = 1) and Haemophilus influenza (n = 1) for non-Down syndrome protocol group.
  5. cOther: parvovirus (n = 1) for Down syndrome protocol group; parainfluenza (n = 3) and rotavirus (n = 2) for non-Down syndrome protocol group.